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- W2055276204 abstract "The TIP60 tumor suppressor is a histone acetyltransferase involved in transcriptional regulation, checkpoint activation, and p53-directed proapoptotic pathways. We report that human papillomavirus (HPV) E6 destabilizes TIP60 both in vivo and in vitro. TIP60 binds to the HPV major early promoter and acetylates histone H4 to recruit Brd4, a cellular repressor of HPV E6 expression. Both low- and high-risk HPV E6 destabilize TIP60, thereby derepressing their own promoter. Destabilization of TIP60 by HPV E6 also relieves cellular promoters from TIP60-initiated repression and abrogates p53-dependent activation of apoptotic pathway. Degradation of TIP60, therefore, allows low- and high-risk HPV to promote cell proliferation and cell survival." @default.
- W2055276204 created "2016-06-24" @default.
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- W2055276204 date "2010-06-01" @default.
- W2055276204 modified "2023-10-13" @default.
- W2055276204 title "Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic Pathway" @default.
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- W2055276204 cites W1975660840 @default.
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- W2055276204 doi "https://doi.org/10.1016/j.molcel.2010.05.020" @default.
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