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• W2055290265 abstract "Objective: To determine the prognostic effect of intratumor microvessel density in a series of unselected patients with endometrial carcinoma. Methods: We reviewed 93 consecutive patients treated surgically for endometrial cancer at the University Hospital of Vienna between 1983 and 1989. Histologic sections were obtained from original paraffin-embedded blocks and stained immunohistochemically for CD34 antigen. Microvessel density was determined by enumeration of intratumor CD34-positive cells under a light microscope at 200× magnification using an examination area of 0.74 mm 2 . Log-rank test and Cox proportional-hazards models (univariate and multivariate) were applied for overall survival analysis. Results: Overall, the 25% quantile of survival was reached at 37.9 months. The 5-year survival rate was 82.2% in 69 patients whose tumors had microvessel counts no more than 100/0.74 mm 2 field, and 52.0% in 24 patients whose tumors had microvessel counts of more than 100/0.74 mm 2 field (log-rank P = .004). In the multiple Cox model, high microvessel counts (relative risk [RR] 1.2; 95% confidence interval [CI] 1.1, 1.4) as well as undifferentiated tumors (RR 6.1; CI 2.2, 16.8), and advanced stage of disease (RR 2.6; CI 1.3, 5.1) independently exerted an adverse influence on the survival of patients with endometrial cancer. Conclusion: High intratumor microvessel count is associated with poor survival of patients with endometrial cancer." @default.
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• W2055290265 date "1999-03-01" @default.
• W2055290265 modified "2023-10-11" @default.
• W2055290265 title "Prognostic significance of tumor angiogenesis in endometrial cancer" @default.
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• W2055290265 doi "https://doi.org/10.1016/s0029-7844(98)00417-7" @default.
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