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- W2055291371 abstract "Abstract Eudragit RS-sulphasalazine microspheres containing up to 0.8% w/w samarium oxide (Sm 2 O 3 ) have been irradiated with neutrons as a potential method for radiolabelling. Following irradiation, no leaching of 153 Sm 2 O 3 from the microspheres was detectable during in vitro dissolution testing. Using HPLC, sulphasalazine appeared to be stable to irradiation. Irradiation resulted in little apparent change in the molecular weight of Eudragit RS, although there were marked changes in the macroscopic and microscopic appearance of the microspheres. The physical changes in the microspheres most obviously manifested themselves in a considerable increase in the rate of sulphasalazine release; the time for 50% of the encapsulated drug to be released was at least halved for all but one microsphere sample. The mechanism by which drug release was enhanced was unclear." @default.
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- W2055291371 date "1993-08-31" @default.
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- W2055291371 title "Radiolabelling of polymer microspheres for scintigraphic investigations by neutron activation. 2. Effects of irradiation on the properties of Eudragit RS-sulphasalazine microspheres" @default.
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- W2055291371 doi "https://doi.org/10.1016/0378-5173(93)90042-e" @default.
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