FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055291483> ?p ?o ?g. }

• W2055291483 endingPage "376" @default.
• W2055291483 startingPage "367" @default.
• W2055291483 abstract "Objective: To compare virological outcome and genotypic resistance profiles in HIV-1-infected patients starting non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimens. Methods: NNRTI-naive patients were included who started treatment with nevirapine (NVP) or efavirenz (EFV) with genotypic resistance test results available at time of initiation (baseline). Virological failure was defined as two consecutive values > 500 copies/ml after starting the regimen. Cox models were used to investigate time to virological failure (the first of two values). Results: A total of 759 patients were included (13% antiretroviral-naive): 389 initiated NVP and 370 initiated EFV. Baseline IAS-USA NNRTI resistance mutations were detected in 3%. Using the Rega algorithm (version 7.1) to interpret resistance, 460 (64%) patients had resistance (full or intermediate) to at least one drug they were starting (69% NVP, 60% EFV, P = 0.011); 287 (74%) NVP and 168 (45%) EFV patients experienced virological failure after treatment initiation, P < 0.001. After adjustment for previous antiretroviral use, previous AIDS, year started NNRTI, CD4 cell count (baseline, nadir), viral load (baseline, maximum), and baseline drug resistance (measured by Rega), the relative hazards (EFV versus NVP) of virological failure was 0.50, 95% confidence interval: 0.39–0.65, P < 0.001. At time of virological failure, comparable levels of NNRTI resistance were detected. The K103N mutation emerged more in patients failing EFV and Y181C in patients failing NVP. Conclusions: NVP may be associated with an inferior virological outcome compared to EFV in NNRTI-naive patients with extensive resistance to other drug classes. The profile of NNRTI resistance mutations when virologically failing an NNRTI-containing regimen appears to depend on the NNRTI the patients fail." @default.
• W2055291483 created "2016-06-24" @default.
• W2055291483 creator A5014663441 @default.
• W2055291483 creator A5016736736 @default.
• W2055291483 creator A5027160828 @default.
• W2055291483 creator A5028130303 @default.
• W2055291483 creator A5031052325 @default.
• W2055291483 creator A5039500086 @default.
• W2055291483 creator A5047438814 @default.
• W2055291483 creator A5066949455 @default.
• W2055291483 creator A5074980560 @default.
• W2055291483 creator A5078701955 @default.
• W2055291483 creator A5080120008 @default.
• W2055291483 date "2008-01-30" @default.
• W2055291483 modified "2023-10-14" @default.
• W2055291483 title "Comparison of genotypic resistance profiles and virological response between patients starting nevirapine and efavirenz in EuroSIDA" @default.
• W2055291483 cites W1539792978 @default.
• W2055291483 cites W1978540833 @default.
• W2055291483 cites W1989307318 @default.
• W2055291483 cites W1991864115 @default.
• W2055291483 cites W2013788600 @default.
• W2055291483 cites W2016885534 @default.
• W2055291483 cites W2020845967 @default.
• W2055291483 cites W2030633257 @default.
• W2055291483 cites W2050621055 @default.
• W2055291483 cites W2056118379 @default.
• W2055291483 cites W2108438793 @default.
• W2055291483 cites W2109598777 @default.
• W2055291483 cites W2110937893 @default.
• W2055291483 cites W2116147749 @default.
• W2055291483 cites W2116801949 @default.
• W2055291483 cites W2117681036 @default.
• W2055291483 cites W2122280827 @default.
• W2055291483 cites W2123087672 @default.
• W2055291483 cites W2130803791 @default.
• W2055291483 cites W2141776019 @default.
• W2055291483 cites W2146329405 @default.
• W2055291483 cites W2180761483 @default.
• W2055291483 cites W2321852728 @default.
• W2055291483 doi "https://doi.org/10.1097/qad.0b013e3282f3cc35" @default.
• W2055291483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18195563" @default.
• W2055291483 hasPublicationYear "2008" @default.
• W2055291483 type Work @default.
• W2055291483 sameAs 2055291483 @default.
• W2055291483 citedByCount "46" @default.
• W2055291483 countsByYear W20552914832012 @default.
• W2055291483 countsByYear W20552914832013 @default.
• W2055291483 countsByYear W20552914832014 @default.
• W2055291483 countsByYear W20552914832015 @default.
• W2055291483 countsByYear W20552914832016 @default.
• W2055291483 countsByYear W20552914832017 @default.
• W2055291483 countsByYear W20552914832020 @default.
• W2055291483 crossrefType "journal-article" @default.
• W2055291483 hasAuthorship W2055291483A5014663441 @default.
• W2055291483 hasAuthorship W2055291483A5016736736 @default.
• W2055291483 hasAuthorship W2055291483A5027160828 @default.
• W2055291483 hasAuthorship W2055291483A5028130303 @default.
• W2055291483 hasAuthorship W2055291483A5031052325 @default.
• W2055291483 hasAuthorship W2055291483A5039500086 @default.
• W2055291483 hasAuthorship W2055291483A5047438814 @default.
• W2055291483 hasAuthorship W2055291483A5066949455 @default.
• W2055291483 hasAuthorship W2055291483A5074980560 @default.
• W2055291483 hasAuthorship W2055291483A5078701955 @default.
• W2055291483 hasAuthorship W2055291483A5080120008 @default.
• W2055291483 hasBestOaLocation W20552914831 @default.
• W2055291483 hasConcept C104317684 @default.
• W2055291483 hasConcept C114851261 @default.
• W2055291483 hasConcept C126322002 @default.
• W2055291483 hasConcept C142462285 @default.
• W2055291483 hasConcept C156719811 @default.
• W2055291483 hasConcept C159047783 @default.
• W2055291483 hasConcept C182707283 @default.
• W2055291483 hasConcept C2777351918 @default.
• W2055291483 hasConcept C2779130552 @default.
• W2055291483 hasConcept C2781413609 @default.
• W2055291483 hasConcept C2781432083 @default.
• W2055291483 hasConcept C2993143319 @default.
• W2055291483 hasConcept C3013748606 @default.
• W2055291483 hasConcept C44249647 @default.
• W2055291483 hasConcept C49105822 @default.
• W2055291483 hasConcept C55493867 @default.
• W2055291483 hasConcept C71924100 @default.
• W2055291483 hasConcept C86803240 @default.
• W2055291483 hasConcept C89423630 @default.
• W2055291483 hasConcept C90924648 @default.
• W2055291483 hasConceptScore W2055291483C104317684 @default.
• W2055291483 hasConceptScore W2055291483C114851261 @default.
• W2055291483 hasConceptScore W2055291483C126322002 @default.
• W2055291483 hasConceptScore W2055291483C142462285 @default.
• W2055291483 hasConceptScore W2055291483C156719811 @default.
• W2055291483 hasConceptScore W2055291483C159047783 @default.
• W2055291483 hasConceptScore W2055291483C182707283 @default.
• W2055291483 hasConceptScore W2055291483C2777351918 @default.
• W2055291483 hasConceptScore W2055291483C2779130552 @default.
• W2055291483 hasConceptScore W2055291483C2781413609 @default.
• W2055291483 hasConceptScore W2055291483C2781432083 @default.
• W2055291483 hasConceptScore W2055291483C2993143319 @default.
• W2055291483 hasConceptScore W2055291483C3013748606 @default.

• next