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- W2055292012 endingPage "370" @default.
- W2055292012 startingPage "337" @default.
- W2055292012 abstract "Tropomodulins are a family of four proteins (Tmods 1-4) that cap the pointed ends of actin filaments in actin cytoskeletal structures in a developmentally regulated and tissue-specific manner. Unique among capping proteins, Tmods also bind tropomyosins (TMs), which greatly enhance the actin filament pointed-end capping activity of Tmods. Tmods are defined by a TM-regulated/Pointed-End Actin Capping (TM-Cap) domain in their unstructured N-terminal portion, followed by a compact, folded Leucine-Rich Repeat/Pointed-End Actin Capping (LRR-Cap) domain. By inhibiting actin monomer association and dissociation from pointed ends, Tmods regulate actin dynamics and turnover, stabilizing actin filament lengths and cytoskeletal architecture. In this review, we summarize the genes, structural features, molecular and biochemical properties, actin regulatory mechanisms, expression patterns, and cell and tissue functions of Tmods. By understanding Tmods' functions in the context of their molecular structure, actin regulation, binding partners, and related variants (leiomodins 1-3), we can draw broad conclusions that can explain the diverse morphological and functional phenotypes that arise from Tmod perturbation experiments in vitro and in vivo. Tmod-based stabilization and organization of intracellular actin filament networks provide key insights into how the emergent properties of the actin cytoskeleton drive tissue morphogenesis and physiology." @default.
- W2055292012 created "2016-06-24" @default.
- W2055292012 creator A5027610214 @default.
- W2055292012 creator A5031819196 @default.
- W2055292012 creator A5036138197 @default.
- W2055292012 creator A5046627365 @default.
- W2055292012 creator A5056807440 @default.
- W2055292012 date "2012-05-04" @default.
- W2055292012 modified "2023-10-03" @default.
- W2055292012 title "Tropomodulins: Pointed-end capping proteins that regulate actin filament architecture in diverse cell types" @default.
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