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- W2055296917 abstract "During the past two years, monoclonal antibodies with enzyme-like catalytic properties have been successfully raised. They catalyse a variety of reactions (hydrolysis of esters, amides and carbonates; bimolecular reactions; cyclization reactions; elimination reactions; asymmetric synthesis) with rate enhancements of up to 6 × 106 fold and high specificity, including enantiomer specificity. Hybrid antibodies containing covalently-linked catalytic or probe groups have been prepared and antibody-mediated peptide hydrolysis catalysed by metal ion complexes has been reported. Catalytic monoclonal antibodies could have wide-ranging, exciting applications in biology, medicine, chemistry and biotechnology." @default.
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- W2055296917 date "1989-11-01" @default.
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- W2055296917 title "Catalytic monoclonal antibodies: tailor-made, enzyme-like catalysts for chemical reactions" @default.
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- W2055296917 doi "https://doi.org/10.1016/0167-7799(89)90112-1" @default.
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