FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055305108> ?p ?o ?g. }

• W2055305108 endingPage "117" @default.
• W2055305108 startingPage "105" @default.
• W2055305108 abstract "The timing, position and mechanism(s) for determining type II cytodifferentiation during mammalian lung development are not known. To approach this problem, we have cultured Theiler stage 16 embryonic B10.A strain mouse lung primordia (12-days gestation, E12) in serumless, chemically defined medium in the presence or absence of dexamethasone (DEX) for periods up to 27 days in vitro. Morphogenesis and cytodifferentiation were evaluated by light and transmission electron microscopy and immunochemical techniques. Pulmonary surfactant-associated apoproteins (PSAP) were initially expressed by type II cells at 16.5-day gestation in vivo. DEX-supplementation to the culture medium resulted in the accelerated expression of PSAP; the apoprotein isoforms (A1, A2, and A3) produced in vitro were comparable to those synthesized during fetal and postnatal in vivo development by high resolution, two-dimensional gel electrophoresis coupled with immunoblot staining. Cultures without DEX produced PSAP A2 and A3 isoforms, but did not produce A1 (26-31 kDa, pI 5.2-5.3). DEX-treated cultures produced more lamellar bodies within type II cells than non-treated controls. The results demonstrate that long-term cultures of embryonic lung primordia express morphogenesis, cytodifferentiation and the synthesis and secretion of PSAP in the absence of exogenous hormones or growth factors. The data set further supports the hypothesis that morphogenesis and type II cytodifferentiation are regulated by autocrine and paracrine factors intrinsic to the embryonic lung developmental program and independent of exogenous hormone controls." @default.
• W2055305108 created "2016-06-24" @default.
• W2055305108 creator A5012918967 @default.
• W2055305108 creator A5029652767 @default.
• W2055305108 creator A5037656968 @default.
• W2055305108 creator A5042049000 @default.
• W2055305108 date "1988-07-01" @default.
• W2055305108 modified "2023-10-18" @default.
• W2055305108 title "Embryonic mouse lung morphogenesis and type II cytodifferentiation in serumless, chemically defined medium using prolonged in vitro cultures" @default.
• W2055305108 cites W1566217656 @default.
• W2055305108 cites W1606423922 @default.
• W2055305108 cites W1980984900 @default.
• W2055305108 cites W1991318853 @default.
• W2055305108 cites W1992321412 @default.
• W2055305108 cites W2000735803 @default.
• W2055305108 cites W2005483320 @default.
• W2055305108 cites W2027770727 @default.
• W2055305108 cites W2046963052 @default.
• W2055305108 cites W2055396768 @default.
• W2055305108 cites W2058161746 @default.
• W2055305108 cites W2060060679 @default.
• W2055305108 cites W2063079100 @default.
• W2055305108 cites W2080036508 @default.
• W2055305108 cites W2081469714 @default.
• W2055305108 cites W2083453910 @default.
• W2055305108 cites W2100837269 @default.
• W2055305108 cites W2111817213 @default.
• W2055305108 cites W2172048985 @default.
• W2055305108 cites W4293247451 @default.
• W2055305108 doi "https://doi.org/10.1016/0045-6039(88)90062-0" @default.
• W2055305108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3061659" @default.
• W2055305108 hasPublicationYear "1988" @default.
• W2055305108 type Work @default.
• W2055305108 sameAs 2055305108 @default.
• W2055305108 citedByCount "53" @default.
• W2055305108 countsByYear W20553051082012 @default.
• W2055305108 countsByYear W20553051082013 @default.
• W2055305108 countsByYear W20553051082014 @default.
• W2055305108 countsByYear W20553051082016 @default.
• W2055305108 countsByYear W20553051082017 @default.
• W2055305108 countsByYear W20553051082018 @default.
• W2055305108 countsByYear W20553051082019 @default.
• W2055305108 crossrefType "journal-article" @default.
• W2055305108 hasAuthorship W2055305108A5012918967 @default.
• W2055305108 hasAuthorship W2055305108A5029652767 @default.
• W2055305108 hasAuthorship W2055305108A5037656968 @default.
• W2055305108 hasAuthorship W2055305108A5042049000 @default.
• W2055305108 hasConcept C104317684 @default.
• W2055305108 hasConcept C126322002 @default.
• W2055305108 hasConcept C128240485 @default.
• W2055305108 hasConcept C134018914 @default.
• W2055305108 hasConcept C145103041 @default.
• W2055305108 hasConcept C145156650 @default.
• W2055305108 hasConcept C153911025 @default.
• W2055305108 hasConcept C170493617 @default.
• W2055305108 hasConcept C184750944 @default.
• W2055305108 hasConcept C196843134 @default.
• W2055305108 hasConcept C207001950 @default.
• W2055305108 hasConcept C40692019 @default.
• W2055305108 hasConcept C54355233 @default.
• W2055305108 hasConcept C55493867 @default.
• W2055305108 hasConcept C58226133 @default.
• W2055305108 hasConcept C71924100 @default.
• W2055305108 hasConcept C7876069 @default.
• W2055305108 hasConcept C81885089 @default.
• W2055305108 hasConcept C86803240 @default.
• W2055305108 hasConcept C87073359 @default.
• W2055305108 hasConcept C95444343 @default.
• W2055305108 hasConceptScore W2055305108C104317684 @default.
• W2055305108 hasConceptScore W2055305108C126322002 @default.
• W2055305108 hasConceptScore W2055305108C128240485 @default.
• W2055305108 hasConceptScore W2055305108C134018914 @default.
• W2055305108 hasConceptScore W2055305108C145103041 @default.
• W2055305108 hasConceptScore W2055305108C145156650 @default.
• W2055305108 hasConceptScore W2055305108C153911025 @default.
• W2055305108 hasConceptScore W2055305108C170493617 @default.
• W2055305108 hasConceptScore W2055305108C184750944 @default.
• W2055305108 hasConceptScore W2055305108C196843134 @default.
• W2055305108 hasConceptScore W2055305108C207001950 @default.
• W2055305108 hasConceptScore W2055305108C40692019 @default.
• W2055305108 hasConceptScore W2055305108C54355233 @default.
• W2055305108 hasConceptScore W2055305108C55493867 @default.
• W2055305108 hasConceptScore W2055305108C58226133 @default.
• W2055305108 hasConceptScore W2055305108C71924100 @default.
• W2055305108 hasConceptScore W2055305108C7876069 @default.
• W2055305108 hasConceptScore W2055305108C81885089 @default.
• W2055305108 hasConceptScore W2055305108C86803240 @default.
• W2055305108 hasConceptScore W2055305108C87073359 @default.
• W2055305108 hasConceptScore W2055305108C95444343 @default.
• W2055305108 hasIssue "2" @default.
• W2055305108 hasLocation W20553051081 @default.
• W2055305108 hasLocation W20553051082 @default.
• W2055305108 hasOpenAccess W2055305108 @default.
• W2055305108 hasPrimaryLocation W20553051081 @default.
• W2055305108 hasRelatedWork W1495497054 @default.
• W2055305108 hasRelatedWork W184483434 @default.
• W2055305108 hasRelatedWork W1995920009 @default.
• W2055305108 hasRelatedWork W2027992491 @default.

• next