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• W2055318815 abstract "Molecular dynamics simulations have been used to search for the accessible conformations of the melanin-concentrating hormone (MCH). The studies have been performed on native MCH and two of its peptide fragments, a cyclic MCH(5-14) fragment and a linear MCH(5-14) fragment. An analysis of the molecular dynamics trajectories of the three peptides indicates that two regions of the peptide have characteristic conformational properties that may be important for the biological activity. One is a region around Gly8, which is conformationally mobile, and the other is around Pro13, which shows unusual rigidity. The molecular dynamics simulation results are discussed in terms of backbone structural features like beta turns, side-chain interactions, and orientations of the disulfide bridge. The results of this analysis are used to suggest new analogues that will modify the conformational features of the peptide and further define the conformational requirements for activity. Finally, the results are related to nmr studies of the peptide and reveal agreements between the experimental nuclear Overhauser effect constraints and some of the accessible conformations obtained from the simulation." @default.
• W2055318815 created "2016-06-24" @default.
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• W2055318815 date "1990-02-15" @default.
• W2055318815 modified "2023-09-27" @default.
• W2055318815 title "Accessible conformations of melanin-concentrating hormone: A molecular dynamics approach" @default.
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• W2055318815 doi "https://doi.org/10.1002/bip.360290315" @default.
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