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- W2055320295 abstract "Progression of alveolar bone resorption during silk ligature-induced acute inflammation in rats was histochemica11y and ultrastructurally observed. Bone resorption has scarcely occurred on the alveolar bone crest between the first maxillary molars and the second molars of the ligated group on day 3, which was determined statistically. This site showed heavy polymorphonuclear leukocyte-dominant inflammatory cell invasion. Osteoblasts and fibroblastic cells have disapPeared, but, osteoclastic bone resorption occurred in the region adlacent to the middle portion of the root. The relationship betwe en inflammatory cell invasion and bone resorption at the crestal region was confirmed in ligated rats receiving indomethacin as an antiinflammatory agent. These animals displayed induction of fibroblastic cells and tartrate-resistant acid phosphatase (TRAP) positive osteoclasts on the crest. Under electron microscopy (TEM), fibroblastic cells, presumably osteoblast-lineage cells, were closely located near osteoclastic cells, suggesting an interaction between osteoclasts and osteoblast-lineage cells. These findings therefore lead us to consider that alveolar bone resorption does not necessarily occur from the crest in acute inflammation, especially when accompanied by an absence of osteoblast-lineage cells. Thus, our findings suggest that initiation of bone resorption caused by acute inflammation involves the presence of osteoblast-lineage cells which enhance osteoclast differentiation." @default.
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- W2055320295 date "1995-01-01" @default.
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- W2055320295 title "Histochemical and ultrastructural characteristics of the alveolar bone resorption in ligature-induced acute inflammation of periodontium in rats." @default.
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- W2055320295 doi "https://doi.org/10.2330/joralbiosci1965.37.462" @default.
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