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• W2055320930 abstract "Abstract The design and the preparation of a small library of 1,4‐diphenyl‐1,2,3‐triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened protein is part of the hedgehog signaling pathway that is inhibited by the lead compound Vismodegib. Based on molecular modeling simulations, seven triazole derivatives of Vismodegib are synthesized and their biological effect on different endothelial, cancer, and cancer stem cell lines is reported." @default.
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• W2055320930 date "2015-02-27" @default.
• W2055320930 modified "2023-10-18" @default.
• W2055320930 title "Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib" @default.
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• W2055320930 doi "https://doi.org/10.1002/cplu.201402435" @default.
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