FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055335964> ?p ?o ?g. }

• W2055335964 endingPage "216" @default.
• W2055335964 startingPage "213" @default.
• W2055335964 abstract "Cocaine addiction is a public health issue in many countries, stressing the need for more effective treatments. As all drugs of abuse, cocaine acts on the brain reward system, increasing dopamine (DA) levels. Other neurotransmitters such as acetylcholine (ACh) are involved in the mechanisms underlying the development and the maintenance of cocaine addiction. ACh plays an important role in learning and memory processes and also regulates DA in some specific regions of the central nervous system. The present study investigated the effects of biperiden, a muscarinic cholinergic (mACh) antagonist in two animal models: conditioned place preference (CPP) and behavioral sensitization. Male C57BL/6J mice were used in both studies. The CPP protocol was unbiased and carried out in three phases: habituation, conditioning and testing. For conditioning, cocaine was injected at a dose of 10mg/kg in eight 15 min-sessions. The treatment with biperiden (doses of 0.1, 1 and 10 mg/kg) was made 30 min prior to the testing session. For behavioral sensitization development, cocaine was administered at the dose of 10 mg/kg for 10 days. After sensitization, two challenges were performed: saline and cocaine (5 mg/kg). Biperiden (10 mg/kg) was administered 30 min before the cocaine challenge. At the dose of 10 mg/kg, biperiden blocked the cocaine-CPP expression, suggesting an effect on conditioned memory retrieval. However, the same dose potentiated the expression of behavioral sensitization, suggesting an increase in DA release, probably in the NAc. Biperiden, as other mACh antagonists, may be a promising drug for the pharmacologic treatment of cocaine addiction." @default.
• W2055335964 created "2016-06-24" @default.
• W2055335964 creator A5006345872 @default.
• W2055335964 creator A5031885366 @default.
• W2055335964 creator A5056653721 @default.
• W2055335964 creator A5075157768 @default.
• W2055335964 creator A5077926189 @default.
• W2055335964 date "2012-05-01" @default.
• W2055335964 modified "2023-09-28" @default.
• W2055335964 title "Biperiden (M1 antagonist) impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization" @default.
• W2055335964 cites W1487894289 @default.
• W2055335964 cites W1495673550 @default.
• W2055335964 cites W1613719983 @default.
• W2055335964 cites W1967384601 @default.
• W2055335964 cites W1982093125 @default.
• W2055335964 cites W1983869923 @default.
• W2055335964 cites W2001710735 @default.
• W2055335964 cites W2005239439 @default.
• W2055335964 cites W2007860377 @default.
• W2055335964 cites W2008741725 @default.
• W2055335964 cites W2012213517 @default.
• W2055335964 cites W2013414032 @default.
• W2055335964 cites W2016096874 @default.
• W2055335964 cites W2019654201 @default.
• W2055335964 cites W2024783245 @default.
• W2055335964 cites W2030689026 @default.
• W2055335964 cites W2034474460 @default.
• W2055335964 cites W2041858605 @default.
• W2055335964 cites W2043163764 @default.
• W2055335964 cites W2050688876 @default.
• W2055335964 cites W2051038489 @default.
• W2055335964 cites W2052534327 @default.
• W2055335964 cites W2053696585 @default.
• W2055335964 cites W2065673262 @default.
• W2055335964 cites W2084856596 @default.
• W2055335964 cites W2087282728 @default.
• W2055335964 cites W2101959021 @default.
• W2055335964 cites W2106102633 @default.
• W2055335964 cites W2108894728 @default.
• W2055335964 cites W2151516463 @default.
• W2055335964 cites W2156482912 @default.
• W2055335964 cites W2157096806 @default.
• W2055335964 cites W2163324649 @default.
• W2055335964 cites W2165398609 @default.
• W2055335964 cites W2172245177 @default.
• W2055335964 cites W2346047599 @default.
• W2055335964 cites W2120500329 @default.
• W2055335964 doi "https://doi.org/10.1016/j.bbr.2012.03.030" @default.
• W2055335964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22469627" @default.
• W2055335964 hasPublicationYear "2012" @default.
• W2055335964 type Work @default.
• W2055335964 sameAs 2055335964 @default.
• W2055335964 citedByCount "19" @default.
• W2055335964 countsByYear W20553359642012 @default.
• W2055335964 countsByYear W20553359642014 @default.
• W2055335964 countsByYear W20553359642015 @default.
• W2055335964 countsByYear W20553359642016 @default.
• W2055335964 countsByYear W20553359642017 @default.
• W2055335964 countsByYear W20553359642018 @default.
• W2055335964 countsByYear W20553359642019 @default.
• W2055335964 countsByYear W20553359642021 @default.
• W2055335964 countsByYear W20553359642022 @default.
• W2055335964 crossrefType "journal-article" @default.
• W2055335964 hasAuthorship W2055335964A5006345872 @default.
• W2055335964 hasAuthorship W2055335964A5031885366 @default.
• W2055335964 hasAuthorship W2055335964A5056653721 @default.
• W2055335964 hasAuthorship W2055335964A5075157768 @default.
• W2055335964 hasAuthorship W2055335964A5077926189 @default.
• W2055335964 hasConcept C126322002 @default.
• W2055335964 hasConcept C15744967 @default.
• W2055335964 hasConcept C169760540 @default.
• W2055335964 hasConcept C170493617 @default.
• W2055335964 hasConcept C2775910092 @default.
• W2055335964 hasConcept C2776217527 @default.
• W2055335964 hasConcept C2776885963 @default.
• W2055335964 hasConcept C35124327 @default.
• W2055335964 hasConcept C48856860 @default.
• W2055335964 hasConcept C50610925 @default.
• W2055335964 hasConcept C513476851 @default.
• W2055335964 hasConcept C71924100 @default.
• W2055335964 hasConcept C98274493 @default.
• W2055335964 hasConceptScore W2055335964C126322002 @default.
• W2055335964 hasConceptScore W2055335964C15744967 @default.
• W2055335964 hasConceptScore W2055335964C169760540 @default.
• W2055335964 hasConceptScore W2055335964C170493617 @default.
• W2055335964 hasConceptScore W2055335964C2775910092 @default.
• W2055335964 hasConceptScore W2055335964C2776217527 @default.
• W2055335964 hasConceptScore W2055335964C2776885963 @default.
• W2055335964 hasConceptScore W2055335964C35124327 @default.
• W2055335964 hasConceptScore W2055335964C48856860 @default.
• W2055335964 hasConceptScore W2055335964C50610925 @default.
• W2055335964 hasConceptScore W2055335964C513476851 @default.
• W2055335964 hasConceptScore W2055335964C71924100 @default.
• W2055335964 hasConceptScore W2055335964C98274493 @default.
• W2055335964 hasIssue "1" @default.
• W2055335964 hasLocation W20553359641 @default.
• W2055335964 hasLocation W20553359642 @default.
• W2055335964 hasOpenAccess W2055335964 @default.

• next