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- W2055344306 abstract "The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in culture against NMDA- but not kainate-mediated excitotoxicity. The effect was structure-dependent: larger macrolide rings were more active. Macrolides did not affect the 3-(2-carboxypiperazin-4yl)-propyl-1-phosphonic acid (CPP) binding or the NMDA-mediated calcium influx." @default.
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- W2055344306 date "1993-10-01" @default.
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- W2055344306 title "Macrolide antibiotics protect neurons in culture against theN-methyl-d-aspartate (NMDA) receptor-mediated toxicity of glutamate" @default.
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- W2055344306 doi "https://doi.org/10.1016/0006-8993(93)90098-8" @default.
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