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• W2055347181 abstract "Leukotrienes (LT) are a newly discovered family of substances generated from arachidonic acid by basophils, macrophages, neutrophils, eosinophils, and human lung tissue. 1 Samuelsson B Hammarstrom S Nomenclature for leukotrienes:. Prostaglandins. 1980; 19: 645 Crossref PubMed Scopus (118) Google Scholar Oxidation of arachidonic acid by lipoxygenase produces the unstable leukotriene LTA4. LTA4 may form LTB4 or C4. LTB4 has potent chemotactic activity for leukocytes. 2 Goetzl EJ Pickett WC Novel structural determinants of the human neutrophil chemotaxic activity of leukotriene. Br J Exp Med. 1981; 153: 482 Crossref PubMed Scopus (140) Google Scholar LTC4, together with its metabolites, LTD4 and LTE4, constitute the slow-reacting substance of anaphylaxis SRS-A. 3 Lewis RA Austen KF Drayen JM Clark DA Marfat A Corey EJ Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources. Proc Natl Acad Sci USA. 1980; 77: 3710 Crossref PubMed Scopus (356) Google Scholar LTC4 and D4 have potent bronchiolar smooth muscle contracting activity. We became interested in the effects of LTs on the pulmonary circulation for the following reasons: 1) LTC4 and D4 increase permeability of postcapillary venules in the systemic circulation; 4 Drayen JM Austen KF Lewis RA Clark DA Goto G Marfat A et al. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci USA. 1980; 77: 4354 Crossref PubMed Scopus (533) Google Scholar , 5 Dahlen SE Bjork J Hedqvist P Arfors KE Hammarstrom S Lindgren JA et al. Leukotrienes promote plasma leakage and leukocyte adhesion in post-capillary venules: In vivo effects with relevance to the acute inflammatory response. Proc Natl Acad Sci USA. 1981; 78: 3887 Crossref PubMed Scopus (785) Google Scholar , 6 Peck MJ Piper PJ Williams TJ The effect of leukotrienes C4 and D4 on the microvasculature of guinea-pig skin. Prostaglandins. 1981; 21: 315 Crossref PubMed Scopus (180) Google Scholar 2) 5-HETE increases sheep lung lymph after endotoxin concurrent with the onset of pulmonary edema; 7 Ogletree ML Brigham KM Oates JA Hubbard WC Increased flux of 5-HETE in sheep lung lymph during pulmonary leukostasis after endotoxin. Fed Proc. 1981; 40: 767 Google Scholar 3) infusion of soybean lipoxygenase induces pulmonary edema in sheep; 8 Smith M Gunther R Zaiss C Flynn J Demling R Pulmonary microvascular injury from lipoxygenase infusion: Comparison with endotoxemia. Circ Shock. 1981; 8: 647 PubMed Google Scholar and 4) infusion of arachidonic acid induces pulmomary edema in excised rabbit lungs. 9 Seeger W Wolf H Stahler G Neuhof H Roka L Increased pulmonary vascular resistance and permeability due to arachidonate metabolism in isolated rabbit lungs. Prostaglandins. 1982; 23: 157 Crossref PubMed Scopus (48) Google Scholar" @default.
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• W2055347181 title "Leukotriene C4 and D4 Increase Pulmonary Vascular Permeability in Excised Rabbit Lungs" @default.
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