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- W2055349218 abstract "We have studied the interaction of bovine liver dihydrofolate reductase with methotrexate and trimetrexate at different temperatures by a flow-microcalorimetric method. Results indicate that dihydrofolate reductase undergoes a partial unfolding below 37°C, and that the binding of antifolate compounds induces a protein refolding. On the other hand, the cofactor NADPH has a stabilizing effect on the thermal transition of the protein, and this protective effect is more pronounced in the range 25–37°C." @default.
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- W2055349218 date "1992-07-01" @default.
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- W2055349218 title "Effects of temperature on the interaction of dihydrofolate reductase with some of its ligands" @default.
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- W2055349218 doi "https://doi.org/10.1016/0040-6031(92)80322-n" @default.
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