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• W2055353922 startingPage "12396" @default.
• W2055353922 abstract "Neuropathic pain resulting from damage to or dysfunction of peripheral nerves is not well understood and difficult to treat. Although CNS hyperexcitability is a critical component, recent findings challenge the neuron-centric view of neuropathic pain etiology and pathology. Indeed, glial cells were shown to play an active role in the initiation and maintenance of pain hypersensitivity. However, the origins of these cells and the triggers that induce their activation have yet to be elucidated. Here we show that, after peripheral nerve injury induced by a partial ligation on the sciatic nerve, in addition to activation of microglia resident to the CNS, hematogenous macrophage/monocyte infiltrate the spinal cord, proliferate, and differentiate into microglia. Signaling from chemokine monocyte chemoattractant protein-1 (MCP-1, CCL2) to its receptor CCR2 is critical in the spinal microglial activation. Indeed, intrathecal injection of MCP-1 caused activation of microglia in wild-type but not in CCR2-deficient mice. Furthermore, treatment with an MCP-1 neutralizing antibody prevented bone marrow-derived microglia (BMDM) infiltration into the spinal cord after nerve injury. In addition, using selective knock-out of CCR2 in resident microglia or BMDM, we found that, although total CCR2 knock-out mice did not develop microglial activation or mechanical allodynia, CCR2 expression in either resident microglia or BMDM is sufficient for the development of mechanical allodynia. Thus, to effectively relieve neuropathic pain, both CNS resident microglia and blood-borne macrophages need to be targeted. These findings also open the door for a novel therapeutic strategy: to take advantage of the natural ability of bone marrow-derived cells to infiltrate selectively affected CNS regions by using these cells as vehicle for targeted drug delivery to inhibit hypersensitivity and chronic pain." @default.
• W2055353922 created "2016-06-24" @default.
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• W2055353922 creator A5017328884 @default.
• W2055353922 creator A5027140673 @default.
• W2055353922 date "2007-11-07" @default.
• W2055353922 modified "2023-10-11" @default.
• W2055353922 title "Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain" @default.
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• W2055353922 cites W1611449349 @default.
• W2055353922 cites W1621991227 @default.
• W2055353922 cites W1652978675 @default.
• W2055353922 cites W1743195063 @default.
• W2055353922 cites W1894599871 @default.
• W2055353922 cites W1965102171 @default.
• W2055353922 cites W1968099474 @default.
• W2055353922 cites W1968259371 @default.
• W2055353922 cites W1973891258 @default.
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• W2055353922 cites W1975585602 @default.
• W2055353922 cites W1980369017 @default.
• W2055353922 cites W1981014302 @default.
• W2055353922 cites W1984025105 @default.
• W2055353922 cites W1986160938 @default.
• W2055353922 cites W1986809710 @default.
• W2055353922 cites W1987332793 @default.
• W2055353922 cites W1990920498 @default.
• W2055353922 cites W2000377675 @default.
• W2055353922 cites W2000814289 @default.
• W2055353922 cites W2003570488 @default.
• W2055353922 cites W2003830841 @default.
• W2055353922 cites W2009761130 @default.
• W2055353922 cites W2010166433 @default.
• W2055353922 cites W2015473510 @default.
• W2055353922 cites W2016621027 @default.
• W2055353922 cites W2024783553 @default.
• W2055353922 cites W2025002129 @default.
• W2055353922 cites W2027927113 @default.
• W2055353922 cites W2036931179 @default.
• W2055353922 cites W2037373328 @default.
• W2055353922 cites W2038725731 @default.
• W2055353922 cites W2040744817 @default.
• W2055353922 cites W2043465498 @default.
• W2055353922 cites W2043974564 @default.
• W2055353922 cites W2044640315 @default.
• W2055353922 cites W2045531190 @default.
• W2055353922 cites W2052193782 @default.
• W2055353922 cites W2052709514 @default.
• W2055353922 cites W2055197670 @default.
• W2055353922 cites W2056148352 @default.
• W2055353922 cites W2059066863 @default.
• W2055353922 cites W2059111671 @default.
• W2055353922 cites W2061631515 @default.
• W2055353922 cites W2062392962 @default.
• W2055353922 cites W2063339343 @default.
• W2055353922 cites W2063441735 @default.
• W2055353922 cites W2063733108 @default.
• W2055353922 cites W2066101855 @default.
• W2055353922 cites W2066796908 @default.
• W2055353922 cites W2067924690 @default.
• W2055353922 cites W2070256863 @default.
• W2055353922 cites W2075871178 @default.
• W2055353922 cites W2080499279 @default.
• W2055353922 cites W2084300785 @default.
• W2055353922 cites W2086187702 @default.
• W2055353922 cites W2092585276 @default.
• W2055353922 cites W2092595668 @default.
• W2055353922 cites W2109759840 @default.
• W2055353922 cites W2116495710 @default.
• W2055353922 cites W2120278774 @default.
• W2055353922 cites W2128994172 @default.
• W2055353922 cites W2129801260 @default.
• W2055353922 cites W2132918091 @default.
• W2055353922 cites W2140139281 @default.
• W2055353922 cites W2148740102 @default.
• W2055353922 cites W2162730620 @default.
• W2055353922 cites W2166622977 @default.
• W2055353922 cites W2170019750 @default.
• W2055353922 cites W2172201406 @default.
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• W2055353922 doi "https://doi.org/10.1523/jneurosci.3016-07.2007" @default.
• W2055353922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673247" @default.
• W2055353922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17989304" @default.
• W2055353922 hasPublicationYear "2007" @default.
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