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• W2055361237 startingPage "151" @default.
• W2055361237 abstract "The purpose of this study was to determine the effects of a fish oil concentrate (FOC) on the in vitro conversion of very low density lipoproteins (VLDL) to intermediate (IDL) and low density lipoproteins (LDL). Six hypertriglyceridemic patients were randomly allocated to receive either placebo (olive oil) or FOC (1 g/14 kg body weight/day) for 4 weeks in a crossover study with a 4-week washout period. The FOC provided 3 g of eicosapentaenoic + docosahexaenoic acid per 70 kg of body weight, and it lowered plasma triglyceride and VLDL cholesterol levels by 35% and 42%, respectively. Decreases in the largest particles (VLDL(1)) were primarily responsible, with no effect noted in smaller VLDL particles (VLDL(2) and VLDL(3)). The FOC increased LDL cholesterol levels by 25% (P < 0.06) but did not affect LDL particle size. VLDL(1) and VLDL(3) were incubated in vitro with human postheparin lipases. Although triglycerides from both types of VLDL were hydrolyzed to the same extent with both treatments, particles isolated during the FOC phase were more readily converted into IDL and LDL than were control particles. These data suggest that the marine omega3 fatty acids may enhance the propensity of VLDL to be converted to LDL, partly explaining the decreased VLDL and increased LDL levels in FOC-treated patients." @default.
• W2055361237 created "2016-06-24" @default.
• W2055361237 creator A5011349903 @default.
• W2055361237 creator A5019717682 @default.
• W2055361237 creator A5050579428 @default.
• W2055361237 date "1999-03-01" @default.
• W2055361237 modified "2023-09-27" @default.
• W2055361237 title "Omega-3 fatty acids alter lipoprotein subfraction distributions and the in vitro conversion of very low density lipoproteins to low density lipoproteins" @default.
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• W2055361237 doi "https://doi.org/10.1016/s0955-2863(98)00094-1" @default.
• W2055361237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15539283" @default.
• W2055361237 hasPublicationYear "1999" @default.
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