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- W2055361823 endingPage "286" @default.
- W2055361823 startingPage "277" @default.
- W2055361823 abstract "Ubiquitylation is a reversible post-translational modification that has emerged as a key regulator of most complex cellular processes. It may rival phosphorylation in scope and exceed it in complexity. The dynamic nature of ubiquitylation events is important for governing protein stability, maintaining ubiquitin homeostasis and controlling ubiquitin-dependent signalling pathways. The human genome encodes ~80 active deubiquitylating enzymes (DUBs, also referred to as deubiquitinases), which exhibit distinct specificity profiles towards the various ubiquitin chain topologies. As a result of their ability to reverse ubiquitylation, these enzymes control a broad range of key cellular processes. In this Commentary we discuss the cellular functions of DUBs, such as their role in governing membrane traffic and protein quality control. We highlight two key signalling pathways – the Wnt and transforming growth factor β (TGF-β) pathways, for which dynamic ubiquitylation has emerged as a key regulator. We also discuss the roles of DUBs in the nucleus, where they govern transcriptional activity and DNA repair pathways." @default.
- W2055361823 created "2016-06-24" @default.
- W2055361823 creator A5019964520 @default.
- W2055361823 creator A5089277444 @default.
- W2055361823 creator A5091908521 @default.
- W2055361823 date "2012-01-15" @default.
- W2055361823 modified "2023-09-23" @default.
- W2055361823 title "Cellular functions of the DUBs" @default.
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