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- W2055362105 abstract "Chronic pulmonary hypertension in infancy and childhood frequently culminates in right-ventricular (RV) failure and early death. Current management may include prolonged treatment with inhaled nitric oxide (iNO). Our objective was to examine the effects of iNO on established chronic hypoxic pulmonary hypertension in juvenile rats, a model of chronic neonatal pulmonary hypertension characterized by increased pulmonary vascular resistance, vascular remodeling (RV hypertrophy and arterial medial wall thickening), and significant RV dysfunction. Pups were exposed to air or hypoxia (13% O(2)) from postnatal day 1 to 21 while receiving iNO (20 ppm) from day 14 to 21. In hypoxia-exposed animals, treatment with iNO decreased pulmonary vascular resistance, but did not augment RV output or reverse vascular remodeling. In addition, RV output was significantly reduced in air-exposed iNO-treated pups. Nitrotyrosine (a marker of peroxynitrite-mediated reactions), apoptosis, and expression of nitric oxide synthases 1 and 2 were increased in RV (but not left-ventricular) tissue from both air- and hypoxia-exposed pups treated with iNO. Concurrent treatment with a peroxynitrite decomposition catalyst (FeTPPS, 30 mg/kg/day, ip) prevented apoptosis and completely normalized RV output in iNO-exposed animals. Our results provide the first evidence that iNO may adversely impact the right ventricle through increased local generation of peroxynitrite." @default.
- W2055362105 created "2016-06-24" @default.
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- W2055362105 date "2010-11-15" @default.
- W2055362105 modified "2023-09-26" @default.
- W2055362105 title "Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats" @default.
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- W2055362105 cites W1725300350 @default.
- W2055362105 cites W1821918060 @default.
- W2055362105 cites W1963639235 @default.
- W2055362105 cites W1964288597 @default.
- W2055362105 cites W1964653374 @default.
- W2055362105 cites W1966959411 @default.
- W2055362105 cites W1968053961 @default.
- W2055362105 cites W1969786711 @default.
- W2055362105 cites W1969847513 @default.
- W2055362105 cites W1975406229 @default.
- W2055362105 cites W1975603544 @default.
- W2055362105 cites W1976188689 @default.
- W2055362105 cites W1978234307 @default.
- W2055362105 cites W1979684615 @default.
- W2055362105 cites W1980458823 @default.
- W2055362105 cites W1986249654 @default.
- W2055362105 cites W1990792990 @default.
- W2055362105 cites W1997568920 @default.
- W2055362105 cites W2005205544 @default.
- W2055362105 cites W2005685810 @default.
- W2055362105 cites W2014217144 @default.
- W2055362105 cites W2017068027 @default.
- W2055362105 cites W2021751181 @default.
- W2055362105 cites W2023032045 @default.
- W2055362105 cites W2028638263 @default.
- W2055362105 cites W2030188224 @default.
- W2055362105 cites W2031072585 @default.
- W2055362105 cites W2033656398 @default.
- W2055362105 cites W2039194785 @default.
- W2055362105 cites W2042273969 @default.
- W2055362105 cites W2043111155 @default.
- W2055362105 cites W2051705991 @default.
- W2055362105 cites W2052022195 @default.
- W2055362105 cites W2052188754 @default.
- W2055362105 cites W2055935493 @default.
- W2055362105 cites W2062315388 @default.
- W2055362105 cites W2074198144 @default.
- W2055362105 cites W2074461681 @default.
- W2055362105 cites W2077633549 @default.
- W2055362105 cites W2078587014 @default.
- W2055362105 cites W2080638516 @default.
- W2055362105 cites W2082062242 @default.
- W2055362105 cites W2084593725 @default.
- W2055362105 cites W2086264689 @default.
- W2055362105 cites W2099159245 @default.
- W2055362105 cites W2099745042 @default.
- W2055362105 cites W2103186593 @default.
- W2055362105 cites W2104844429 @default.
- W2055362105 cites W2104989112 @default.
- W2055362105 cites W2105247741 @default.
- W2055362105 cites W2105862640 @default.
- W2055362105 cites W2109850479 @default.
- W2055362105 cites W2112859269 @default.
- W2055362105 cites W2112893975 @default.
- W2055362105 cites W2116532275 @default.
- W2055362105 cites W2116684609 @default.
- W2055362105 cites W2122386753 @default.
- W2055362105 cites W2124853732 @default.
- W2055362105 cites W2131447300 @default.
- W2055362105 cites W2131474149 @default.
- W2055362105 cites W2131616732 @default.
- W2055362105 cites W2133931336 @default.
- W2055362105 cites W2135289666 @default.
- W2055362105 cites W2137137239 @default.
- W2055362105 cites W2139664452 @default.
- W2055362105 cites W2145785767 @default.
- W2055362105 cites W2148026002 @default.
- W2055362105 cites W2158402737 @default.
- W2055362105 cites W2161208671 @default.
- W2055362105 cites W2164047272 @default.
- W2055362105 cites W2167432569 @default.
- W2055362105 cites W2169799265 @default.
- W2055362105 cites W2399225952 @default.
- W2055362105 cites W2403132134 @default.
- W2055362105 cites W2475293453 @default.
- W2055362105 doi "https://doi.org/10.1016/j.freeradbiomed.2010.08.007" @default.
- W2055362105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20708678" @default.
- W2055362105 hasPublicationYear "2010" @default.
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