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• W2055363086 startingPage "937" @default.
• W2055363086 abstract "Zebrafish (Danio rerio) is becoming an increasingly popular vertebrate cancer model. In this study, we established a xenotransplanted zebrafish embryo glioma model to further investigate the molecular mechanisms of tumor angiogenesis. We find that the glioma cell line U87 can survive, proliferate and induce additional SIV branches in zebrafish embryos. In addition, by the means of in situ hybridization and quantitive RT-PCR analyses we find that the transplanted U87 cells can induce the ectopic zebrafish vascular endothelial growth factor A (VEGF A) and its receptor VEGFR2/KDR mRNA expression and increase their expression levels, resulting in additional SIV branches." @default.
• W2055363086 created "2016-06-24" @default.
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• W2055363086 date "2012-06-12" @default.
• W2055363086 modified "2023-09-24" @default.
• W2055363086 title "VEGF induces angiogenesis in a zebrafish embryo glioma model established by transplantation of human glioma cells" @default.
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• W2055363086 doi "https://doi.org/10.3892/or.2012.1861" @default.
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