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- W2055363584 abstract "To study the value of the nuchal translucency (NT) measurement in the screening for chromosomal abnormalities at 10–14 weeks of gestation. 1152 fetuses were studied consecutively. In 124 cases a cytogenetic study was performed on material obtained from a biopsy of the chorionic villus, and in 1028 cases the post-natal phenotype was used as a basis for the result. In addition to the routine ultrasonographic examination, all the fetuses were submitted to measurement of the NT thickness. For statistical analysis the T “student” test and ANOVA were used. The sensitivity, specificity, positive and negative predictive values, false-positive rate and likelihood ratio were calculated. Twenty-three cases of chromosomal abnormalities occurred. Of these abnormal cases, NT measurement was above 95 centile in 16, the sensitivity was 69.5%. In the group of normal fetuses (1129 cases), NT measurement was above 95 centile in 41 (specificity of 96.3%, positive and negative predictive values of 28.0% and 99.3%, respectively), the false-positive rate was 3.7% and likelihood ratio was 19.1. Our results suggest that the presence of chromosomal abnormalities may be strongly suspected when there is an increased NT thickness. One can infer that the NT quantitative analysis is sufficient to classify the risk of chromosomal anomalies in the first trimester of the pregnancy. Although the ultrasound operator training and skill is still necessary, it is a method of feasible clinical applicability." @default.
- W2055363584 created "2016-06-24" @default.
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- W2055363584 date "2003-01-01" @default.
- W2055363584 modified "2023-10-02" @default.
- W2055363584 title "P023: Screening for fetal trisomies by fetal nuchal translucency thickness at 10-14 weeks of gestation" @default.
- W2055363584 doi "https://doi.org/10.1002/uog.483" @default.
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