FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055365557> ?p ?o ?g. }

• W2055365557 endingPage "1074" @default.
• W2055365557 startingPage "1069" @default.
• W2055365557 abstract "The novel anxiolytic drug buspirone raised striatal levels of the dopamine metabolites homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) 1 hr after oral administration. This effect was dose-dependent with a peak at 60 min. No changes were observed in the levels of 3-methyxytyramine (3MT), the extraneuronal metabolite of dopamine. Noradrenaline, serotonin and its metabolite 5-hydroxyindoleacetic acid (5HIAA) were not affected. Buspirone displaced [3H]spiroperidol from striatal binding sites, with an ic50 (1.8 × 10−7 M), comparable to that of clozapine (ic50 = 1.4 × 10−7M) but considerably lower than that of haloperidol (4.7 × 10−9 M). Buspirone was only a weak inhibitor of dopamine-stimulated adenyl cyclase. Buspirone was not active on the binding of trifluoperazine to calmodulin and did not modify calmodulin-induced activation of phosphodiesterase (PDE). Repeated administration of buspirone did not increase the number of DA receptors. These data show that, although buspirone has antidopaminergic activity, it can hardly be classified as a classic neuroleptic agent." @default.
• W2055365557 created "2016-06-24" @default.
• W2055365557 creator A5033032639 @default.
• W2055365557 creator A5049630365 @default.
• W2055365557 creator A5060441165 @default.
• W2055365557 creator A5073550160 @default.
• W2055365557 creator A5077095217 @default.
• W2055365557 creator A5080578570 @default.
• W2055365557 creator A5081979241 @default.
• W2055365557 date "1983-03-01" @default.
• W2055365557 modified "2023-10-18" @default.
• W2055365557 title "Dopaminergic effects of buspirone, a novel anxiolytic agent" @default.
• W2055365557 cites W1812428887 @default.
• W2055365557 cites W1970233340 @default.
• W2055365557 cites W1975216040 @default.
• W2055365557 cites W1997024999 @default.
• W2055365557 cites W2004279416 @default.
• W2055365557 cites W2005781708 @default.
• W2055365557 cites W2029264635 @default.
• W2055365557 cites W2042609824 @default.
• W2055365557 cites W2045690336 @default.
• W2055365557 cites W2057645285 @default.
• W2055365557 cites W2072883732 @default.
• W2055365557 cites W2140506109 @default.
• W2055365557 cites W2141804782 @default.
• W2055365557 cites W2224345851 @default.
• W2055365557 cites W2253302896 @default.
• W2055365557 cites W2329442555 @default.
• W2055365557 cites W2411424630 @default.
• W2055365557 cites W2462958848 @default.
• W2055365557 cites W938650580 @default.
• W2055365557 doi "https://doi.org/10.1016/0006-2952(83)90627-5" @default.
• W2055365557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6838654" @default.
• W2055365557 hasPublicationYear "1983" @default.
• W2055365557 type Work @default.
• W2055365557 sameAs 2055365557 @default.
• W2055365557 citedByCount "65" @default.
• W2055365557 countsByYear W20553655572013 @default.
• W2055365557 countsByYear W20553655572019 @default.
• W2055365557 crossrefType "journal-article" @default.
• W2055365557 hasAuthorship W2055365557A5033032639 @default.
• W2055365557 hasAuthorship W2055365557A5049630365 @default.
• W2055365557 hasAuthorship W2055365557A5060441165 @default.
• W2055365557 hasAuthorship W2055365557A5073550160 @default.
• W2055365557 hasAuthorship W2055365557A5077095217 @default.
• W2055365557 hasAuthorship W2055365557A5080578570 @default.
• W2055365557 hasAuthorship W2055365557A5081979241 @default.
• W2055365557 hasConcept C126322002 @default.
• W2055365557 hasConcept C134018914 @default.
• W2055365557 hasConcept C137183658 @default.
• W2055365557 hasConcept C149151106 @default.
• W2055365557 hasConcept C170493617 @default.
• W2055365557 hasConcept C185592680 @default.
• W2055365557 hasConcept C2775841634 @default.
• W2055365557 hasConcept C2775864247 @default.
• W2055365557 hasConcept C2777287423 @default.
• W2055365557 hasConcept C2777477808 @default.
• W2055365557 hasConcept C2777765862 @default.
• W2055365557 hasConcept C2780948584 @default.
• W2055365557 hasConcept C513476851 @default.
• W2055365557 hasConcept C55493867 @default.
• W2055365557 hasConcept C71924100 @default.
• W2055365557 hasConcept C86803240 @default.
• W2055365557 hasConcept C98274493 @default.
• W2055365557 hasConceptScore W2055365557C126322002 @default.
• W2055365557 hasConceptScore W2055365557C134018914 @default.
• W2055365557 hasConceptScore W2055365557C137183658 @default.
• W2055365557 hasConceptScore W2055365557C149151106 @default.
• W2055365557 hasConceptScore W2055365557C170493617 @default.
• W2055365557 hasConceptScore W2055365557C185592680 @default.
• W2055365557 hasConceptScore W2055365557C2775841634 @default.
• W2055365557 hasConceptScore W2055365557C2775864247 @default.
• W2055365557 hasConceptScore W2055365557C2777287423 @default.
• W2055365557 hasConceptScore W2055365557C2777477808 @default.
• W2055365557 hasConceptScore W2055365557C2777765862 @default.
• W2055365557 hasConceptScore W2055365557C2780948584 @default.
• W2055365557 hasConceptScore W2055365557C513476851 @default.
• W2055365557 hasConceptScore W2055365557C55493867 @default.
• W2055365557 hasConceptScore W2055365557C71924100 @default.
• W2055365557 hasConceptScore W2055365557C86803240 @default.
• W2055365557 hasConceptScore W2055365557C98274493 @default.
• W2055365557 hasIssue "6" @default.
• W2055365557 hasLocation W20553655571 @default.
• W2055365557 hasLocation W20553655572 @default.
• W2055365557 hasOpenAccess W2055365557 @default.
• W2055365557 hasPrimaryLocation W20553655571 @default.
• W2055365557 hasRelatedWork W1968633470 @default.
• W2055365557 hasRelatedWork W2006136814 @default.
• W2055365557 hasRelatedWork W2013675762 @default.
• W2055365557 hasRelatedWork W2017638447 @default.
• W2055365557 hasRelatedWork W2018655226 @default.
• W2055365557 hasRelatedWork W2027596383 @default.
• W2055365557 hasRelatedWork W2035465482 @default.
• W2055365557 hasRelatedWork W2055365557 @default.
• W2055365557 hasRelatedWork W2060828139 @default.
• W2055365557 hasRelatedWork W2171454471 @default.
• W2055365557 hasVolume "32" @default.
• W2055365557 isParatext "false" @default.

• next