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• W2055366591 abstract "The accumulation of radioactive cyclic AMP was examined in [14C]adeninelabeled slices of guinea pig neocortex following in vivo treatments designed to lower the levels of putative neurotransmitters such as norepinephrine, serotonin, and histamine. Lesions of the medial forebrain bundle and treatment with 6-hydroxydopamine or reserpine decreased cortical concentrations of norepinephrine in guinea pig. Based on studies in rats, enhanced responses of norepinephrine-sensitive cortical cyclic AMP-generating systems were to be expected after such treatments. Instead, no evidence for enhanced responses of cyclic AMP-generating systems to norepinephrine, serotonin, or histamine was obtained with cortical slices from the treated guinea pigs. Adenosine-sensitive cyclic AMP-generating systems in guinea pig cortical slices did become hyperresponsive after reserpine." @default.
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• W2055366591 date "1976-08-01" @default.
• W2055366591 modified "2023-10-18" @default.
• W2055366591 title "Norepinephrine depletion and responsiveness of norepinephrine-sensitive cyclic AMP generating systems in guinea pig brain" @default.
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• W2055366591 doi "https://doi.org/10.1016/0014-4886(76)90165-5" @default.
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