Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055366823> ?p ?o ?g. }
- W2055366823 endingPage "14" @default.
- W2055366823 startingPage "1" @default.
- W2055366823 abstract "Bone metabolism requires tightly coupled activities exhibited by two unique cell populations, the bone-resorbing osteoclasts and the bone-forming osteoblasts. Imbalance in the function of these two cell types can result in osteoporosis, a condition characterized by loss in bone integrity and of bone mass. We developed a human bone cell culture model that allows the in vitro study of bone formation and osteoclastogenesis and employed this bone model for the screening and pharmacological analyses of protein and small molecule therapeutics. The cytokines, interleukin-6 (IL-6) and granulocyte macrophage colony stimulating factor (GM-CSF), play an intricate role in osteoclastogenesis in this system. Neutralizing antibodies to IL-6 and GM-CSF decreased the formation of osteoclast-like cells. SP500263, an early lead compound from a novel class of selective estrogen receptor modulators (SERMs), was more efficacious than estrogen and comparable to raloxifene in blocking cytokine production and formation of osteoclast-like cells. Our research demonstrates the usefulness of the in vitro co-culture model in the dissection of molecular events relevant to bone metabolism and provides greater insight into a potential novel role for cytokines in bone resorption. Furthermore, representatives of the SP500263 family of SERMs may be effective as therapeutics for the treatment of osteoporosis." @default.
- W2055366823 created "2016-06-24" @default.
- W2055366823 creator A5006313979 @default.
- W2055366823 creator A5027109947 @default.
- W2055366823 creator A5027767506 @default.
- W2055366823 creator A5035472398 @default.
- W2055366823 creator A5066986688 @default.
- W2055366823 creator A5069264475 @default.
- W2055366823 creator A5071927763 @default.
- W2055366823 creator A5081492222 @default.
- W2055366823 creator A5081766635 @default.
- W2055366823 creator A5085765161 @default.
- W2055366823 date "2003-07-01" @default.
- W2055366823 modified "2023-10-01" @default.
- W2055366823 title "SP500263, a novel SERM, blocks osteoclastogenesis in a human bone cell model: role of IL-6 and GM-CSF" @default.
- W2055366823 cites W1537488315 @default.
- W2055366823 cites W1634178576 @default.
- W2055366823 cites W1966592306 @default.
- W2055366823 cites W1966816365 @default.
- W2055366823 cites W1967301186 @default.
- W2055366823 cites W1977031949 @default.
- W2055366823 cites W1981306061 @default.
- W2055366823 cites W1988177550 @default.
- W2055366823 cites W1993004730 @default.
- W2055366823 cites W1996028579 @default.
- W2055366823 cites W2000624726 @default.
- W2055366823 cites W2004163214 @default.
- W2055366823 cites W2004584881 @default.
- W2055366823 cites W2005523878 @default.
- W2055366823 cites W2006665329 @default.
- W2055366823 cites W2011311044 @default.
- W2055366823 cites W2016020334 @default.
- W2055366823 cites W2018814475 @default.
- W2055366823 cites W2019146941 @default.
- W2055366823 cites W2021821328 @default.
- W2055366823 cites W2024073334 @default.
- W2055366823 cites W2029100291 @default.
- W2055366823 cites W2030085659 @default.
- W2055366823 cites W2031328252 @default.
- W2055366823 cites W2031723224 @default.
- W2055366823 cites W2033793521 @default.
- W2055366823 cites W2034488466 @default.
- W2055366823 cites W2039119391 @default.
- W2055366823 cites W2045258828 @default.
- W2055366823 cites W2053526776 @default.
- W2055366823 cites W2060441344 @default.
- W2055366823 cites W2061906660 @default.
- W2055366823 cites W2062106031 @default.
- W2055366823 cites W2062252312 @default.
- W2055366823 cites W2062720655 @default.
- W2055366823 cites W2064797437 @default.
- W2055366823 cites W2066062971 @default.
- W2055366823 cites W2066318392 @default.
- W2055366823 cites W2074551181 @default.
- W2055366823 cites W2078455816 @default.
- W2055366823 cites W2084102864 @default.
- W2055366823 cites W2084535197 @default.
- W2055366823 cites W2084541510 @default.
- W2055366823 cites W2087438535 @default.
- W2055366823 cites W2093349314 @default.
- W2055366823 cites W2093360232 @default.
- W2055366823 cites W2097304380 @default.
- W2055366823 cites W2097339826 @default.
- W2055366823 cites W2099990122 @default.
- W2055366823 cites W2118767606 @default.
- W2055366823 cites W2124954136 @default.
- W2055366823 cites W2125168145 @default.
- W2055366823 cites W2131357215 @default.
- W2055366823 cites W2132675666 @default.
- W2055366823 cites W2143417141 @default.
- W2055366823 cites W2149124413 @default.
- W2055366823 cites W2159674010 @default.
- W2055366823 cites W2161623422 @default.
- W2055366823 cites W2161719531 @default.
- W2055366823 cites W2169758044 @default.
- W2055366823 cites W2171740113 @default.
- W2055366823 cites W2317600447 @default.
- W2055366823 cites W2397079531 @default.
- W2055366823 cites W2403616646 @default.
- W2055366823 cites W3044574244 @default.
- W2055366823 doi "https://doi.org/10.1016/s1043-4666(03)00179-0" @default.
- W2055366823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12901849" @default.
- W2055366823 hasPublicationYear "2003" @default.
- W2055366823 type Work @default.
- W2055366823 sameAs 2055366823 @default.
- W2055366823 citedByCount "20" @default.
- W2055366823 countsByYear W20553668232014 @default.
- W2055366823 countsByYear W20553668232015 @default.
- W2055366823 countsByYear W20553668232019 @default.
- W2055366823 countsByYear W20553668232022 @default.
- W2055366823 countsByYear W20553668232023 @default.
- W2055366823 crossrefType "journal-article" @default.
- W2055366823 hasAuthorship W2055366823A5006313979 @default.
- W2055366823 hasAuthorship W2055366823A5027109947 @default.
- W2055366823 hasAuthorship W2055366823A5027767506 @default.
- W2055366823 hasAuthorship W2055366823A5035472398 @default.
- W2055366823 hasAuthorship W2055366823A5066986688 @default.
- W2055366823 hasAuthorship W2055366823A5069264475 @default.