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- W2055366954 abstract "diography and catheterization. (-)-CGP12177 treatment in healthy mice increased heart rate and left ventricular (LV) contractility. In mice subjected to an 8-week period of aorta banding, (-)-CGP12177 treatment during weeks 4–8 led to a positive inotropic effect, but exacerbated LV hypertrophy by 9% (estimated by weight, wall thickness, cardiomyocyte size) and interstitial/perivascular fibrosis (by histology). Importantly, (-)-CGP12177 treatment to aorta banded mice exacerbated myocardial expression of hypertrophic, fibrogenic and inflammatory genes (all p< 0.05 vs. non-treated mice with aorta banding). Conclusion: 1LAR activation provides functional support to the heart, in both normal and diseased (pressure overload) settings. Sustained 1LAR activation in the diseasedheart exacerbatesLVremodellingand thereforemay promote disease progression from compensatory hypertrophy to heart failure. doi:10.1016/j.hlc.2010.06.791" @default.
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- W2055366954 date "2010-01-01" @default.
- W2055366954 modified "2023-10-04" @default.
- W2055366954 title "Sex-Based Differences in Contractility and Ca2+ Homeostasis in Cardiomyocytes from Primary Hypertrophic Hearts" @default.
- W2055366954 doi "https://doi.org/10.1016/j.hlc.2010.06.792" @default.
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