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• W2055367774 startingPage "66" @default.
• W2055367774 abstract "The effects of 5alpha-androsten-3alpha-ol (ASE), and retinoic acids (RAs) and their precursors on the phenobarbital (PB)-mediated induction of CYP2B1 and 2B2 were examined in cultured rat hepatocytes. Two isomers of RA, 9-cis- and all-trans-RA, suppressed markedly the effect of PB on CYP2B1/2 expression, while ASE had no suppressive effect. The effect of 9-cis-RA appeared at a lower concentration than the all-trans-isomer, indicating the dominant action of the former isomer. Suppression with 9-cis-retinal was also observed, but all-trans-retinol and -retinal were without effect. These results suggest that: (1) ASE, an inverse agonist for the constitutive androstane receptor (CAR), does not play a major role in the suppression of the CYP2B; (2) 9-cis-RA suppresses CYP2B induction by reducing ligand-free retinoid X-receptors (RXR) available for dimerization with the CAR; and (3) enzymes responsible for RA formation play an important role in the mechanism governing CYP2B regulation." @default.
• W2055367774 created "2016-06-24" @default.
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• W2055367774 date "2000-10-01" @default.
• W2055367774 modified "2023-10-14" @default.
• W2055367774 title "Suppression of the Expression of the CYP2B1/2 Gene by Retinoic Acids" @default.
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• W2055367774 doi "https://doi.org/10.1006/bbrc.2000.3620" @default.
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