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- W2055372408 abstract "Herpesvirus replication within host cells results in concatemeric genomic DNA, which is cleaved into unit-length genomes and packaged into the capsid by a complex of proteins. The sites of cleavage have been identified for many herpesviruses, and conserved signaling sequences involved in cleavage and packaging have been characterized. The cleavage/packaging motifs pac-1, pac-2, and DR1 and two distinct groups of telomeric repeat sequences (static TRS and variable TRS) have been identified. By sequencing the termini of the gallid herpesvirus type 2 (GaHV-2) strain CU-2, two different cleavage sites (classical and aberrant) have been identified. Unlike classical cleavage of human herpesvirus type 1, which occurs within the DR1 site, classical cleavage of the GaHV-2 concatemers occurs 8.5 bp upstream of the DR1 site and results in an S-terminus containing telomeric repeats. Aberrant cleavage occurs the same distance from the DR1 site and generates a telomeric S-terminus but an L-terminus lacking an a sequence. These results are consistent with previous findings in other herpesviruses and should prove useful in the future study and manipulation of the GaHV-2 genome." @default.
- W2055372408 created "2016-06-24" @default.
- W2055372408 creator A5024281158 @default.
- W2055372408 creator A5030297307 @default.
- W2055372408 date "2013-06-01" @default.
- W2055372408 modified "2023-10-03" @default.
- W2055372408 title "Identification and Characterization of the Genomic Termini and Cleavage/Packaging Signals of Gallid Herpesvirus Type 2" @default.
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- W2055372408 doi "https://doi.org/10.1637/10410-100312-reg.1" @default.
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