FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055386000> ?p ?o ?g. }

• W2055386000 endingPage "159" @default.
• W2055386000 startingPage "150" @default.
• W2055386000 abstract "EGFR inhibitors, including the small-molecule tyrosine kinase inhibitors such as gefitinib, and the monoclonal antibodies directed at the receptor such as cetuximab, have demonstrated promising effects in non-small cell lung cancer (NSCLC). In this study, we generated cetuximab-resistant cell lines (HCC827-CR) from HCC827 NSCLC cells to investigate acquired resistance mechanisms to cetuximab. In HCC827-CR cells, Akt was hyperactivated and its activity was persistent upon cetuximab treatment. Blockade of PI3K/Akt activity restored cetuximab sensitivity in HCC827-CR cells. Further investigation revealed that increased PTEN instability mediates constitutive Akt activation. By 1microM proteosomal inhibitor, MG-132, PTEN protein levels were restored and Akt activity was dramatically reduced. Overexpression of PTEN by transfection could not restore cetuximab sensitivity in HCC827-CR because overexpressed PTEN was degraded rapidly ( approximately 72h). The increased PTEN instability was confirmed by the treatment of HCC827-CR with a protein synthesis inhibitor, cycloheximide. In the presence of cycloheximide, overexpressed PTEN was degraded more rapidly ( approximately 12h) in HCC827-CR cells. Interestingly, HCC827-CR cells also revealed de novo resistance to gefitinib. Inhibition of PI3K/Akt signaling pathway restored sensitivity to gefitinib in HCC827-CR cells. Taken together, these data show that PTEN instability-mediated constitutive Akt activation is involved in acquired resistance mechanisms to cetuximab and also induces de novo resistance to gefitinib. Importantly, these findings suggest emergence of cross-resistance between two agents as a potential serious problem in the clinical setting." @default.
• W2055386000 created "2016-06-24" @default.
• W2055386000 creator A5005358526 @default.
• W2055386000 creator A5023568164 @default.
• W2055386000 creator A5028314308 @default.
• W2055386000 creator A5048178386 @default.
• W2055386000 creator A5063765651 @default.
• W2055386000 creator A5064697305 @default.
• W2055386000 creator A5070801716 @default.
• W2055386000 creator A5078229156 @default.
• W2055386000 creator A5087673406 @default.
• W2055386000 date "2010-10-01" @default.
• W2055386000 modified "2023-09-27" @default.
• W2055386000 title "Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells" @default.
• W2055386000 cites W1964071325 @default.
• W2055386000 cites W1964321121 @default.
• W2055386000 cites W1973777839 @default.
• W2055386000 cites W1975540192 @default.
• W2055386000 cites W1978068596 @default.
• W2055386000 cites W1978916359 @default.
• W2055386000 cites W1980157504 @default.
• W2055386000 cites W1988769784 @default.
• W2055386000 cites W1998971866 @default.
• W2055386000 cites W2004439203 @default.
• W2055386000 cites W2005204942 @default.
• W2055386000 cites W2005631145 @default.
• W2055386000 cites W2015946454 @default.
• W2055386000 cites W2016710415 @default.
• W2055386000 cites W2029633750 @default.
• W2055386000 cites W2039633811 @default.
• W2055386000 cites W2059780149 @default.
• W2055386000 cites W2068345721 @default.
• W2055386000 cites W2068427129 @default.
• W2055386000 cites W2070732456 @default.
• W2055386000 cites W2086444954 @default.
• W2055386000 cites W2099658407 @default.
• W2055386000 cites W2101778620 @default.
• W2055386000 cites W2107693250 @default.
• W2055386000 cites W2114048774 @default.
• W2055386000 cites W2115199224 @default.
• W2055386000 cites W2122553809 @default.
• W2055386000 cites W2133488997 @default.
• W2055386000 cites W2138604360 @default.
• W2055386000 cites W2139236349 @default.
• W2055386000 cites W2140334822 @default.
• W2055386000 cites W2168340462 @default.
• W2055386000 cites W2168479321 @default.
• W2055386000 cites W4246015058 @default.
• W2055386000 doi "https://doi.org/10.1016/j.canlet.2010.04.006" @default.
• W2055386000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20444542" @default.
• W2055386000 hasPublicationYear "2010" @default.
• W2055386000 type Work @default.
• W2055386000 sameAs 2055386000 @default.
• W2055386000 citedByCount "55" @default.
• W2055386000 countsByYear W20553860002012 @default.
• W2055386000 countsByYear W20553860002013 @default.
• W2055386000 countsByYear W20553860002014 @default.
• W2055386000 countsByYear W20553860002015 @default.
• W2055386000 countsByYear W20553860002016 @default.
• W2055386000 countsByYear W20553860002017 @default.
• W2055386000 countsByYear W20553860002019 @default.
• W2055386000 countsByYear W20553860002021 @default.
• W2055386000 countsByYear W20553860002022 @default.
• W2055386000 countsByYear W20553860002023 @default.
• W2055386000 crossrefType "journal-article" @default.
• W2055386000 hasAuthorship W2055386000A5005358526 @default.
• W2055386000 hasAuthorship W2055386000A5023568164 @default.
• W2055386000 hasAuthorship W2055386000A5028314308 @default.
• W2055386000 hasAuthorship W2055386000A5048178386 @default.
• W2055386000 hasAuthorship W2055386000A5063765651 @default.
• W2055386000 hasAuthorship W2055386000A5064697305 @default.
• W2055386000 hasAuthorship W2055386000A5070801716 @default.
• W2055386000 hasAuthorship W2055386000A5078229156 @default.
• W2055386000 hasAuthorship W2055386000A5087673406 @default.
• W2055386000 hasConcept C121608353 @default.
• W2055386000 hasConcept C126322002 @default.
• W2055386000 hasConcept C2777609662 @default.
• W2055386000 hasConcept C2779438470 @default.
• W2055386000 hasConcept C2779998722 @default.
• W2055386000 hasConcept C2780580887 @default.
• W2055386000 hasConcept C502942594 @default.
• W2055386000 hasConcept C526805850 @default.
• W2055386000 hasConcept C62478195 @default.
• W2055386000 hasConcept C71924100 @default.
• W2055386000 hasConcept C75217442 @default.
• W2055386000 hasConcept C86554907 @default.
• W2055386000 hasConcept C86803240 @default.
• W2055386000 hasConcept C95444343 @default.
• W2055386000 hasConceptScore W2055386000C121608353 @default.
• W2055386000 hasConceptScore W2055386000C126322002 @default.
• W2055386000 hasConceptScore W2055386000C2777609662 @default.
• W2055386000 hasConceptScore W2055386000C2779438470 @default.
• W2055386000 hasConceptScore W2055386000C2779998722 @default.
• W2055386000 hasConceptScore W2055386000C2780580887 @default.
• W2055386000 hasConceptScore W2055386000C502942594 @default.
• W2055386000 hasConceptScore W2055386000C526805850 @default.
• W2055386000 hasConceptScore W2055386000C62478195 @default.
• W2055386000 hasConceptScore W2055386000C71924100 @default.

• next