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• W2055393361 endingPage "e109186" @default.
• W2055393361 startingPage "e109186" @default.
• W2055393361 abstract "Like many other ancient genes, the cystic fibrosis transmembrane conductance regulator (CFTR) has survived for hundreds of millions of years. In this report, we consider whether such prodigious longevity of an individual gene – as opposed to an entire genome or species – should be considered surprising in the face of eons of relentless DNA replication errors, mutagenesis, and other causes of sequence polymorphism. The conventions that modern human SNP patterns result either from purifying selection or random (neutral) drift were not well supported, since extant models account rather poorly for the known plasticity and function (or the established SNP distributions) found in a multitude of genes such as CFTR. Instead, our analysis can be taken as a polemic indicating that SNPs in CFTR and many other mammalian genes may have been generated—and continue to accrue—in a fundamentally more organized manner than would otherwise have been expected. The resulting viewpoint contradicts earlier claims of ‘directional’ or ‘intelligent design-type’ SNP formation, and has important implications regarding the pace of DNA adaptation, the genesis of conserved non-coding DNA, and the extent to which eukaryotic SNP formation should be viewed as adaptive." @default.
• W2055393361 created "2016-06-24" @default.
• W2055393361 creator A5001361146 @default.
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• W2055393361 creator A5076454980 @default.
• W2055393361 creator A5088271450 @default.
• W2055393361 date "2014-10-28" @default.
• W2055393361 modified "2023-09-26" @default.
• W2055393361 title "Longevity and Plasticity of CFTR Provide an Argument for Noncanonical SNP Organization in Hominid DNA" @default.
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• W2055393361 doi "https://doi.org/10.1371/journal.pone.0109186" @default.
• W2055393361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4211684" @default.
• W2055393361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25350658" @default.

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