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- W2055393410 abstract "Following infection with the trematode helminth Schistosoma mansoni, CBA mice develop severe parasite egg-induced hepatic granulomatous inflammation as well as prominent CD4+ T helper 17 (Th17) cell responses driven by dendritic cell (DC)-derived IL-1β and IL-23. By comparison, C57BL/6 mice develop mild hepatic immunopathology, egg stimulation of DCs does not result in IL-1β and IL-23 production, and Th17 cells fail to develop. To investigate the reasons for strain-specific differences in antigen presenting cell (APC) reactivity to eggs, we performed a comparative gene profiling analysis of normal bone marrow-derived DCs (BMDCs) and found that CBA DCs display markedly elevated expression of C-type lectin receptors (CLRs). In particular, expression of CD209a, a murine homologue of human DC-specific ICAM-3-grabbing non-integrin (DC-SIGN, CD209), was strikingly higher in CBA than BL/6 DCs. High CD209a surface expression was observed in various CBA splenic and granuloma APC subpopulations; however, only DCs, and not macrophages, B cells or neutrophils, were able to induce Th17 cell differentiation in response to schistosome eggs. Lentiviral gene silencing in CBA DCs, and over-expression in BL/6 DCs, demonstrated CD209a to be critical for egg-induced DC IL-1β and IL-23 production necessary for Th17 cell differentiation and expansion. These findings reveal a novel innate parasite-sensing mechanism promoting CD4+ Th17 cells that mediate severe immunopathology in schistosomiasis." @default.
- W2055393410 created "2016-06-24" @default.
- W2055393410 creator A5003592690 @default.
- W2055393410 creator A5046292753 @default.
- W2055393410 date "2015-11-01" @default.
- W2055393410 modified "2023-10-01" @default.
- W2055393410 title "Dendritic cell expression of the C-type lectin receptor CD209a: A novel innate parasite-sensing mechanism inducing Th17 cells that drive severe immunopathology in murine schistosome infection" @default.
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- W2055393410 doi "https://doi.org/10.1016/j.exppara.2015.04.006" @default.
- W2055393410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618778" @default.
- W2055393410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25913088" @default.
- W2055393410 hasPublicationYear "2015" @default.
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