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• W2055396976 abstract "During the first 2 years of life the adequate nutritional status (NS) maintenance is crucial to ensure full growth and development. Evaluate changes in NS of infants undergoing HSCT in Curitiba-Brazil during hospitalization and the long-term impact in the NS. Analyze the nutritional therapy applied and implications of this intervention to the patient's outcome. Data was collected retrospectively from medical records considering the anthropometry at the time of hospitalization and last outpatient visit. All pts younger than 2 years-old, transplanted between 12/1990 and 11/2007 were included. 53pts were included, 38 (72%) were male, age was 13.5±6.2 months, 43 pts (81%) had non malignant diseases, 29 (55%) received HSCT from unrelated donors. At hospitalization 17 pts (32%) showed mild to moderate malnutrition and 8 pts (15%) severe malnutrition. At hospital discharge, 21 pts (40%) showed mild to moderate malnutrition and 9 pts (17%) severe malnutrition. During hospitalization 6 pts (11%) lost 5-10% of body weight and 3 pts (6%) lost over 10%. There was no relationship between the baseline NS and survival, and between pathology, length of hospital stay and weight loss. 14 pts (26%) received tube feeding (TF) for 12.7±11.5 days, to supply an average of 30.4 kcal/kg/day and 0.9 g protein/kg/day. 22 (42%) patients received parenteral nutrition (PN) for 15.7±6.1 days to supply 49.8 kcal/kg/day and 1.5 g protein/kg/day. There was no statistical difference in the incidence of vomiting, diarrhea and hyperglycemia among patients who received TF, PN or exclusively oral feeding. 30 pts survived at least one year with a median follow up of 2540±1448 days. Age was 6.4±3.9 years at the latest evaluation, 11 pts (33%) developed GVHD. Regarding the current NS, 19 pts (58%) had short stature, 13 pts (39%) showed mild to moderate malnutrition and 4 pts (12%) had severe malnutrition. Analyzing the height/age curve, 15 pts (45%) did not reach an ascendant growth curve after HSCT and 14 pts (42%) did not reach an ascendant weight/age curve. We observed a high prevalence of malnutrition prior to HSCT and many pts persisted with long term deficits in height and weight after transplant. The use of TF did not lead to increased gastrointestinal complications and could be used in order to prevent weight loss during HSCT and diminish nutritional long term complications." @default.
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• W2055396976 date "2010-02-01" @default.
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• W2055396976 title "Long-Term Impact Of Hematopoietic Stem Cell Transplantation On The Nutritional Status Of Infants" @default.
• W2055396976 doi "https://doi.org/10.1016/j.bbmt.2009.12.292" @default.
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