FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055403225> ?p ?o ?g. }

• W2055403225 endingPage "306" @default.
• W2055403225 startingPage "295" @default.
• W2055403225 abstract "β3-Adrenergic receptor agonists are currently under clinical development for the treatment of overactive bladder, a condition that is prevalent in postmenopausal women. These agents purportedly relax bladder smooth muscle through a direct action at the myocyte β3-receptor. The aim of this study was to examine the expression of the individual beta-adrenergic receptors in full thickness sections from ageing human female bladder. We obtained a series of rabbit polyclonal antibodies generated against each of the three β-adrenergic receptors, and validated their receptor specificity in CHOK1 cells expressing each of the individual receptors. Immunostaining for β1, β2, and β3 were each more prominent in the urothelium than in the detrusor, with all receptors expressed in the same cell types, indicating co-expression of all three receptors throughout the urothelium in addition to the detrusor. Staining of all receptors was also observed in suburothelial myofibroblast-like cells, intramural ganglion cells, and in Schwann cells of intramural nerves. The β3-receptor in the human urothelium appears to be functional, as two different selective β3-receptor agonists, TAK677 and BRL37344, stimulate cAMP formation in UROtsa cells. Densitometry analysis indicates a persistent expression of all receptors throughout the bladder with increasing age, with the exception of the β2-receptor in the urothelium of the trigone, which appears to decrease slightly in older women. These data indicate that β3-receptor expression is maintained with age, but may function in concert with other β-receptors. Activation of the myocyte receptor may be influenced by action on non-myocyte structures including the intramural ganglion cells and myofibroblasts." @default.
• W2055403225 created "2016-06-24" @default.
• W2055403225 creator A5014135786 @default.
• W2055403225 creator A5031171170 @default.
• W2055403225 creator A5038150085 @default.
• W2055403225 creator A5070718835 @default.
• W2055403225 creator A5073213455 @default.
• W2055403225 creator A5078179672 @default.
• W2055403225 date "2010-10-16" @default.
• W2055403225 modified "2023-10-18" @default.
• W2055403225 title "β−Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder" @default.
• W2055403225 cites W1632083014 @default.
• W2055403225 cites W1965160493 @default.
• W2055403225 cites W1967300240 @default.
• W2055403225 cites W1969279276 @default.
• W2055403225 cites W1972504105 @default.
• W2055403225 cites W1973959787 @default.
• W2055403225 cites W1980809057 @default.
• W2055403225 cites W1984693557 @default.
• W2055403225 cites W1985366863 @default.
• W2055403225 cites W1985491990 @default.
• W2055403225 cites W1985689558 @default.
• W2055403225 cites W1992879600 @default.
• W2055403225 cites W1995242730 @default.
• W2055403225 cites W1999506482 @default.
• W2055403225 cites W2004962395 @default.
• W2055403225 cites W2008969125 @default.
• W2055403225 cites W2013146205 @default.
• W2055403225 cites W2014996904 @default.
• W2055403225 cites W2022360041 @default.
• W2055403225 cites W2028950695 @default.
• W2055403225 cites W2029187954 @default.
• W2055403225 cites W2033285271 @default.
• W2055403225 cites W2047698832 @default.
• W2055403225 cites W2050991739 @default.
• W2055403225 cites W2062936582 @default.
• W2055403225 cites W2063434544 @default.
• W2055403225 cites W2066686985 @default.
• W2055403225 cites W2070432389 @default.
• W2055403225 cites W2079117821 @default.
• W2055403225 cites W2084222484 @default.
• W2055403225 cites W2086755401 @default.
• W2055403225 cites W2100620477 @default.
• W2055403225 cites W2101230394 @default.
• W2055403225 cites W2104967317 @default.
• W2055403225 cites W2108637054 @default.
• W2055403225 cites W2111165009 @default.
• W2055403225 cites W2133352920 @default.
• W2055403225 cites W2147220948 @default.
• W2055403225 cites W2148884191 @default.
• W2055403225 doi "https://doi.org/10.1007/s00441-010-1053-x" @default.
• W2055403225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3113530" @default.
• W2055403225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20953633" @default.
• W2055403225 hasPublicationYear "2010" @default.
• W2055403225 type Work @default.
• W2055403225 sameAs 2055403225 @default.
• W2055403225 citedByCount "62" @default.
• W2055403225 countsByYear W20554032252012 @default.
• W2055403225 countsByYear W20554032252013 @default.
• W2055403225 countsByYear W20554032252014 @default.
• W2055403225 countsByYear W20554032252015 @default.
• W2055403225 countsByYear W20554032252016 @default.
• W2055403225 countsByYear W20554032252017 @default.
• W2055403225 countsByYear W20554032252018 @default.
• W2055403225 countsByYear W20554032252019 @default.
• W2055403225 countsByYear W20554032252020 @default.
• W2055403225 countsByYear W20554032252022 @default.
• W2055403225 countsByYear W20554032252023 @default.
• W2055403225 crossrefType "journal-article" @default.
• W2055403225 hasAuthorship W2055403225A5014135786 @default.
• W2055403225 hasAuthorship W2055403225A5031171170 @default.
• W2055403225 hasAuthorship W2055403225A5038150085 @default.
• W2055403225 hasAuthorship W2055403225A5070718835 @default.
• W2055403225 hasAuthorship W2055403225A5073213455 @default.
• W2055403225 hasAuthorship W2055403225A5078179672 @default.
• W2055403225 hasBestOaLocation W20554032252 @default.
• W2055403225 hasConcept C126322002 @default.
• W2055403225 hasConcept C134018914 @default.
• W2055403225 hasConcept C170493617 @default.
• W2055403225 hasConcept C207200792 @default.
• W2055403225 hasConcept C2777540882 @default.
• W2055403225 hasConcept C2778938600 @default.
• W2055403225 hasConcept C2780616540 @default.
• W2055403225 hasConcept C2910041100 @default.
• W2055403225 hasConcept C2993002077 @default.
• W2055403225 hasConcept C40465926 @default.
• W2055403225 hasConcept C71924100 @default.
• W2055403225 hasConcept C77411442 @default.
• W2055403225 hasConcept C86803240 @default.
• W2055403225 hasConcept C95444343 @default.
• W2055403225 hasConceptScore W2055403225C126322002 @default.
• W2055403225 hasConceptScore W2055403225C134018914 @default.
• W2055403225 hasConceptScore W2055403225C170493617 @default.
• W2055403225 hasConceptScore W2055403225C207200792 @default.
• W2055403225 hasConceptScore W2055403225C2777540882 @default.
• W2055403225 hasConceptScore W2055403225C2778938600 @default.
• W2055403225 hasConceptScore W2055403225C2780616540 @default.
• W2055403225 hasConceptScore W2055403225C2910041100 @default.

• next