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- W2055403933 abstract "The interaction of myosin crossbridges with actin under equilibrium conditions is reviewed. Similarities and differences between the weakly- and strongly-binding interactions of myosin crossbridges with actin filaments are discussed. A precise, narrow definition of weakly-binding crossbridges is given. It is postulated that the fundamental difference between the weakly- and strongly-binding equilibrium interaction of crossbridges with actin is that the crossbridge heads are mobile after attachment in the first case but not in the second. It is argued that because the weakly-binding crossbridge heads are mobile after attachment, the heads appear to function independently of each other. The lack of head mobility in attached strongly-binding crossbridges makes the strongly-binding crossbridge heads appear to act cooperatively. This model of the strongly-binding crossbridge gives an explanation for two important and otherwise unexplained observations. It explains why the rate constant of force decay after a small stretch is a sigmoidal function of nucleotide analogue concentration, and why, in the presence of analogues or in rigor, the rate constant of force decay after a small stretch is often significantly slower than the rate constant for myosin subfragment-1 detachment from actin in solution. The model of the weakly-binding crossbridge accurately describes the behavior of the myosin-ATP crossbridge." @default.
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- W2055403933 date "1993-01-01" @default.
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- W2055403933 title "Equilibrium muscle crossbridge behavior: The interaction of myosin crossbridges with actin" @default.
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- W2055403933 doi "https://doi.org/10.1016/0065-227x(93)90005-p" @default.
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