FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055408934> ?p ?o ?g. }

• W2055408934 endingPage "4397" @default.
• W2055408934 startingPage "4385" @default.
• W2055408934 abstract "The fragile X syndrome is caused by the lack of fragile X mental retardation protein (FMRP) attributable to silencing of the FMR1 gene. The metabotropic glutamate receptors (mGluRs) in the CNS contribute to different brain functions, including learning/memory, mental disorders, drug addiction, and persistent pain. Most of the previous studies have been focused on downstream targets of FMRP in hippocampal neurons, and fewer studies have been reported for the second-messenger signaling pathways between group I mGluRs and FMRP. Furthermore, no molecular study has been performed in the anterior cingulate cortex (ACC), a key region involved in high brain cognitive and executive functions. In this study, we demonstrate that activation of group I mGluR upregulated FMRP in ACC neurons of adult mice through the Ca 2+ -dependent signaling pathways. Using genetic approaches, we found that Ca 2+ /calmodulin-stimulated adenylyl cyclase 1 (AC1) and calcium/calmodulin-dependent kinase IV (CaMKIV) contribute to the upregulation of FMRP induced by stimulating group I mGluRs. The upregulation of FMRP occurs at the transcriptional level. The cAMP-dependent protein kinase is activated by stimulating group I mGluRs through AC1 in ACC neurons. Both AC1 and CaMKIV contribute to the regulation of FMRP by group I mGluRs probably through cAMP response element-binding protein activation. Our study has provided the first evidence for a molecular link between group I mGluRs and FMRP in ACC neurons and may help us to understand the pathogenesis of fragile X syndrome." @default.
• W2055408934 created "2016-06-24" @default.
• W2055408934 creator A5004035910 @default.
• W2055408934 creator A5030797138 @default.
• W2055408934 creator A5036502653 @default.
• W2055408934 creator A5082449329 @default.
• W2055408934 date "2008-04-23" @default.
• W2055408934 modified "2023-10-16" @default.
• W2055408934 title "Roles of Calcium-Stimulated Adenylyl Cyclase and Calmodulin-Dependent Protein Kinase IV in the Regulation of FMRP by Group I Metabotropic Glutamate Receptors" @default.
• W2055408934 cites W1481828225 @default.
• W2055408934 cites W1483057098 @default.
• W2055408934 cites W1558012505 @default.
• W2055408934 cites W1782908816 @default.
• W2055408934 cites W1960607431 @default.
• W2055408934 cites W1964603653 @default.
• W2055408934 cites W1972385185 @default.
• W2055408934 cites W1972952358 @default.
• W2055408934 cites W1979707864 @default.
• W2055408934 cites W1986218781 @default.
• W2055408934 cites W1992206604 @default.
• W2055408934 cites W1998037132 @default.
• W2055408934 cites W1998232402 @default.
• W2055408934 cites W2000434144 @default.
• W2055408934 cites W2002457970 @default.
• W2055408934 cites W2002760096 @default.
• W2055408934 cites W2007042563 @default.
• W2055408934 cites W2007532395 @default.
• W2055408934 cites W2008374286 @default.
• W2055408934 cites W2013718038 @default.
• W2055408934 cites W2021038734 @default.
• W2055408934 cites W2023396177 @default.
• W2055408934 cites W2026402282 @default.
• W2055408934 cites W2027467098 @default.
• W2055408934 cites W2029662567 @default.
• W2055408934 cites W2029950812 @default.
• W2055408934 cites W2031785254 @default.
• W2055408934 cites W2032435549 @default.
• W2055408934 cites W2034967383 @default.
• W2055408934 cites W2038905876 @default.
• W2055408934 cites W2040118711 @default.
• W2055408934 cites W2047636274 @default.
• W2055408934 cites W2055234453 @default.
• W2055408934 cites W2058861807 @default.
• W2055408934 cites W2060957843 @default.
• W2055408934 cites W2063185070 @default.
• W2055408934 cites W2064723730 @default.
• W2055408934 cites W2074728653 @default.
• W2055408934 cites W2075009214 @default.
• W2055408934 cites W2080352350 @default.
• W2055408934 cites W2081539897 @default.
• W2055408934 cites W2083673419 @default.
• W2055408934 cites W2085984991 @default.
• W2055408934 cites W2093335984 @default.
• W2055408934 cites W2094693066 @default.
• W2055408934 cites W2094795912 @default.
• W2055408934 cites W2101024344 @default.
• W2055408934 cites W2106189180 @default.
• W2055408934 cites W2106196793 @default.
• W2055408934 cites W2108563170 @default.
• W2055408934 cites W2116276594 @default.
• W2055408934 cites W2120552228 @default.
• W2055408934 cites W2136497405 @default.
• W2055408934 cites W2137385309 @default.
• W2055408934 cites W2142319091 @default.
• W2055408934 cites W2146445418 @default.
• W2055408934 cites W2149580098 @default.
• W2055408934 cites W2150873111 @default.
• W2055408934 cites W2157468016 @default.
• W2055408934 cites W2158434083 @default.
• W2055408934 cites W2160765931 @default.
• W2055408934 cites W2165104370 @default.
• W2055408934 cites W2168221097 @default.
• W2055408934 cites W2168750565 @default.
• W2055408934 cites W2171154298 @default.
• W2055408934 cites W2409697517 @default.
• W2055408934 cites W4211181349 @default.
• W2055408934 cites W4231944272 @default.
• W2055408934 cites W4237122850 @default.
• W2055408934 doi "https://doi.org/10.1523/jneurosci.0646-08.2008" @default.
• W2055408934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6670940" @default.
• W2055408934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18434517" @default.
• W2055408934 hasPublicationYear "2008" @default.
• W2055408934 type Work @default.
• W2055408934 sameAs 2055408934 @default.
• W2055408934 citedByCount "32" @default.
• W2055408934 countsByYear W20554089342012 @default.
• W2055408934 countsByYear W20554089342013 @default.
• W2055408934 countsByYear W20554089342014 @default.
• W2055408934 countsByYear W20554089342015 @default.
• W2055408934 countsByYear W20554089342016 @default.
• W2055408934 countsByYear W20554089342017 @default.
• W2055408934 countsByYear W20554089342018 @default.
• W2055408934 countsByYear W20554089342022 @default.
• W2055408934 crossrefType "journal-article" @default.
• W2055408934 hasAuthorship W2055408934A5004035910 @default.
• W2055408934 hasAuthorship W2055408934A5030797138 @default.
• W2055408934 hasAuthorship W2055408934A5036502653 @default.
• W2055408934 hasAuthorship W2055408934A5082449329 @default.

• next