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- W2055415513 abstract "Le cycle pyrimidinique de la (diamino-2,4 pyrimidinyl-5)-6 méthoxy-2 naphtalènedione-1,4 (14) est obtenu par cycloaddition de la guanidine sur un α-cyanocéténedithioacétal. La fonction quinone résulte de l'oxydation de l'amine primaire correspondante par le nitrosodisulfonate de potassium (réactif de Frémy). La cytotoxicité de cette quinone 14 est prometteuse. Cycloaddition of guanidine to a α-cyaanoketene-S,S-diacetal gave the pyrimidine ring of the 6-(2,4-diamino-5-pyrimidinyl0-2-methoxy-1, 4-naphthalendeione (14). The quinonoid function was obtained by oxidation of the corresponding primary amine by potassium nitrosodisulfonate (Fremy's reagent). The cytotoxicity of this quinone is promising." @default.
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- W2055415513 date "1987-05-01" @default.
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- W2055415513 title "Hétérocycles à fonction quinone.10.Synthèse et activité cytotoxique de la (diamino-2,4 pyrimidinyl-5)-6 méthoxy-2 naphtalènedione-1,4" @default.
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- W2055415513 doi "https://doi.org/10.1002/jhet.5570240307" @default.
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