Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055419602> ?p ?o ?g. }
- W2055419602 endingPage "1607" @default.
- W2055419602 startingPage "1597" @default.
- W2055419602 abstract "Abstract High intrahepatic expression levels of interferon stimulated genes (ISGs) in chronic hepatitis C patients are associated with poor response to interferon plus ribavirin combination therapy. Expression levels of 16 genes (OAS1, PKR, MxA, ISG15, RIG‐I, TLR8, IRF7, IRF9, NFKBIA, IL28A/IL28B, IL29, IL28RA, IL10RB, IFNAR2, and STAT1) that promote antiviral state and 4 genes (SOCS1, SOCS3, Zc3h12a, and A20) that suppress antiviral state were analyzed using real‐time PCR assays in 133 liver biopsy samples from patients infected with genotypes 1 or 2. Expression levels of genes promoting antiviral state were positively correlated with each other but were not correlated with those that suppress antiviral state. Expression levels of some ISGs were inversely associated with common polymorphisms within the IL28B locus. Genes promoting antiviral state were expressed lower (e.g., ISG15, P = 1.42E‐12 and MxA, P = 6.40E‐11) in individuals with the protective rs12979860 CC genotype, and genes suppressing antiviral state were expressed higher (A20, P = 0.00107 and Zc3h12a, P = 0.00129, respectively), although some ISGs were not significant after the Bonferroni correction. The expression levels of both an antiviral (MxA) and a suppressor (SOCS1) ISG were independent predictors for non‐response. These results suggest that rs12979860 genotype may be associated with response to combination therapy through an inverse relationship between antiviral and suppressor ISGs in the liver. J. Med. Virol. 83:1597–1607, 2011. © 2011 Wiley‐Liss, Inc." @default.
- W2055419602 created "2016-06-24" @default.
- W2055419602 creator A5000894813 @default.
- W2055419602 creator A5019763674 @default.
- W2055419602 creator A5021393447 @default.
- W2055419602 creator A5022484621 @default.
- W2055419602 creator A5023958825 @default.
- W2055419602 creator A5027695992 @default.
- W2055419602 creator A5032983935 @default.
- W2055419602 creator A5044269436 @default.
- W2055419602 creator A5063059796 @default.
- W2055419602 creator A5070035943 @default.
- W2055419602 creator A5072877214 @default.
- W2055419602 creator A5079171795 @default.
- W2055419602 date "2011-07-07" @default.
- W2055419602 modified "2023-10-12" @default.
- W2055419602 title "Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state" @default.
- W2055419602 cites W1553915701 @default.
- W2055419602 cites W1974406305 @default.
- W2055419602 cites W1975519799 @default.
- W2055419602 cites W1979065789 @default.
- W2055419602 cites W1982350119 @default.
- W2055419602 cites W2011500811 @default.
- W2055419602 cites W2012893948 @default.
- W2055419602 cites W2013092102 @default.
- W2055419602 cites W2016205218 @default.
- W2055419602 cites W2018828712 @default.
- W2055419602 cites W2026614040 @default.
- W2055419602 cites W2027252289 @default.
- W2055419602 cites W2027545702 @default.
- W2055419602 cites W2032980717 @default.
- W2055419602 cites W2034641125 @default.
- W2055419602 cites W2035413743 @default.
- W2055419602 cites W2036928562 @default.
- W2055419602 cites W2038576929 @default.
- W2055419602 cites W2041421438 @default.
- W2055419602 cites W2058538904 @default.
- W2055419602 cites W2063285149 @default.
- W2055419602 cites W2063520656 @default.
- W2055419602 cites W2063783484 @default.
- W2055419602 cites W2077467499 @default.
- W2055419602 cites W2078586740 @default.
- W2055419602 cites W2086414517 @default.
- W2055419602 cites W2091223358 @default.
- W2055419602 cites W2098484899 @default.
- W2055419602 cites W2102079012 @default.
- W2055419602 cites W2102518994 @default.
- W2055419602 cites W2105764241 @default.
- W2055419602 cites W2107513655 @default.
- W2055419602 cites W2112876622 @default.
- W2055419602 cites W2118505908 @default.
- W2055419602 cites W2123387115 @default.
- W2055419602 cites W2124641180 @default.
- W2055419602 cites W2127685726 @default.
- W2055419602 cites W2129415910 @default.
- W2055419602 cites W2134175118 @default.
- W2055419602 cites W2134194979 @default.
- W2055419602 cites W2137303998 @default.
- W2055419602 cites W2152320056 @default.
- W2055419602 cites W2153346747 @default.
- W2055419602 cites W2154982571 @default.
- W2055419602 cites W2157135427 @default.
- W2055419602 cites W2159954692 @default.
- W2055419602 cites W2163559237 @default.
- W2055419602 cites W2166580125 @default.
- W2055419602 cites W2169686453 @default.
- W2055419602 cites W2335845212 @default.
- W2055419602 doi "https://doi.org/10.1002/jmv.22158" @default.
- W2055419602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21739451" @default.
- W2055419602 hasPublicationYear "2011" @default.
- W2055419602 type Work @default.
- W2055419602 sameAs 2055419602 @default.
- W2055419602 citedByCount "28" @default.
- W2055419602 countsByYear W20554196022012 @default.
- W2055419602 countsByYear W20554196022013 @default.
- W2055419602 countsByYear W20554196022014 @default.
- W2055419602 countsByYear W20554196022015 @default.
- W2055419602 countsByYear W20554196022016 @default.
- W2055419602 countsByYear W20554196022017 @default.
- W2055419602 countsByYear W20554196022020 @default.
- W2055419602 crossrefType "journal-article" @default.
- W2055419602 hasAuthorship W2055419602A5000894813 @default.
- W2055419602 hasAuthorship W2055419602A5019763674 @default.
- W2055419602 hasAuthorship W2055419602A5021393447 @default.
- W2055419602 hasAuthorship W2055419602A5022484621 @default.
- W2055419602 hasAuthorship W2055419602A5023958825 @default.
- W2055419602 hasAuthorship W2055419602A5027695992 @default.
- W2055419602 hasAuthorship W2055419602A5032983935 @default.
- W2055419602 hasAuthorship W2055419602A5044269436 @default.
- W2055419602 hasAuthorship W2055419602A5063059796 @default.
- W2055419602 hasAuthorship W2055419602A5070035943 @default.
- W2055419602 hasAuthorship W2055419602A5072877214 @default.
- W2055419602 hasAuthorship W2055419602A5079171795 @default.
- W2055419602 hasConcept C104317684 @default.
- W2055419602 hasConcept C126042315 @default.
- W2055419602 hasConcept C135763542 @default.
- W2055419602 hasConcept C136449434 @default.
- W2055419602 hasConcept C14077384 @default.