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• W2055422020 startingPage "297" @default.
• W2055422020 abstract "Summary Disturbances of neuronal Ca 2+ homeostasis are considered to be important determinants of age‐related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a rat model of ‘normal’ aging. In this review, we will describe some changes that we have observed in Ca 2+ signaling of aged BF neurons and the reversal of one of these changes by dietary caloric restriction. Our evidence supports a scenario in which subtle changes in the properties of voltage‐gated Ca 2+ channels result in increased Ca 2+ influx during aging. This increased Ca 2+ , in turn, triggers an increase in rapid Ca 2+ buffering in the somatic compartment of aged BF neurons. However, this nominal ‘compensation’, along with other changes in Ca 2+ handling machinery (notably mitochondria) alters the Ca 2+ signal with age in a way that is dependent on the magnitude of the Ca 2+ load. By combining whole‐cell patch clamp electrophysiology, ratiometric Ca 2+ ‐sensitive microfluorimetry and single‐cell reverse transcription‐polymerase chain reaction, we have determined that age‐related rapid buffering changes are present in identified cholinergic BF neurons and that these changes can be prevented by a caloric restriction dietary regimen. Because caloric restriction extends lifespan and retards the progression of age‐related dysfunction, these findings suggest that increased Ca 2+ buffering in cholinergic neurons may be relevant to cognitive decline during normal aging. Importantly, calcium homeostatic mechanisms of BF cholinergic neurons are amenable to dietary interventions that could promote cognitive health during aging." @default.
• W2055422020 created "2016-06-24" @default.
• W2055422020 creator A5056523873 @default.
• W2055422020 creator A5067530177 @default.
• W2055422020 date "2007-03-27" @default.
• W2055422020 modified "2023-10-11" @default.
• W2055422020 title "Calcium buffering systems and calcium signaling in aged rat basal forebrain neurons" @default.
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• W2055422020 doi "https://doi.org/10.1111/j.1474-9726.2007.00293.x" @default.
• W2055422020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2810842" @default.
• W2055422020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17517040" @default.
• W2055422020 hasPublicationYear "2007" @default.
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