Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055433725> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2055433725 abstract "Interferons potentiate the cytotoxic effects of certain antineoplastic drugs on human tumor cells both in vitro and in vivo, although the mechanism of interferon's synergistic action is unknown. Interferon may act by modulating the expression of DNA repair activity in cells. To test this hypothesis, we maintained parallel cultures of normal O6-methylguanine repair-proficient human fibroblasts and tumor cells, or RSV-and SV40-transformed repair-deficient Mer- human fibroblasts in medium containing 0, 100, 500 or 680 U/ml human interferon alpha or beta; after 1-10 weeks, cultures were challenged with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG, CAS: 70-25-7) and assayed for colony-forming ability. Based on the dose at 99% lethality, MNNG cytotoxicity was potentiated from 1.3- to 9-fold in interferon-treated cultures, compared with control cultures (no interferon). A significant potentiation was observed both with Mer+ normal fibroblasts (KD strain) and tumor cells (HOS) and with Mer- SV40-transformed fibroblasts (IMR90-830 and GM638) as well as with RSV-transformed cells (RHOS). However, the degree of potentiation was greater in Mer- virus-transformed cells than in Mer+ cells. The greatest effects were observed with Mer- IMR90-830 cells (5- to 9-fold reduction of dose at 99% lethality). Therefore, because the Mer+ phenotype is not required in order for HuIFNs to sensitize cells to killing by MNNG, interferon does not act by modulating O6-methylguanine repair. However, the effect of interferon on O6-methylguanine-DNA methyltransferase levels and on DNA excision repair should be examined in future experiments." @default.
- W2055433725 created "2016-06-24" @default.
- W2055433725 creator A5036231109 @default.
- W2055433725 creator A5089450919 @default.
- W2055433725 date "1989-01-01" @default.
- W2055433725 modified "2023-09-25" @default.
- W2055433725 title "Synergistic killing of virus-transformed human cells with interferon and N-methyl-N'-nitro-N-nitrosoguanidine" @default.
- W2055433725 doi "https://doi.org/10.1093/carcin/10.2.265" @default.
- W2055433725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2463881" @default.
- W2055433725 hasPublicationYear "1989" @default.
- W2055433725 type Work @default.
- W2055433725 sameAs 2055433725 @default.
- W2055433725 citedByCount "6" @default.
- W2055433725 crossrefType "journal-article" @default.
- W2055433725 hasAuthorship W2055433725A5036231109 @default.
- W2055433725 hasAuthorship W2055433725A5089450919 @default.
- W2055433725 hasConcept C104317684 @default.
- W2055433725 hasConcept C109316439 @default.
- W2055433725 hasConcept C134935766 @default.
- W2055433725 hasConcept C153911025 @default.
- W2055433725 hasConcept C154317977 @default.
- W2055433725 hasConcept C159047783 @default.
- W2055433725 hasConcept C202751555 @default.
- W2055433725 hasConcept C207001950 @default.
- W2055433725 hasConcept C2776178377 @default.
- W2055433725 hasConcept C2780381497 @default.
- W2055433725 hasConcept C2780625556 @default.
- W2055433725 hasConcept C501734568 @default.
- W2055433725 hasConcept C54355233 @default.
- W2055433725 hasConcept C552990157 @default.
- W2055433725 hasConcept C55493867 @default.
- W2055433725 hasConcept C81885089 @default.
- W2055433725 hasConcept C86803240 @default.
- W2055433725 hasConceptScore W2055433725C104317684 @default.
- W2055433725 hasConceptScore W2055433725C109316439 @default.
- W2055433725 hasConceptScore W2055433725C134935766 @default.
- W2055433725 hasConceptScore W2055433725C153911025 @default.
- W2055433725 hasConceptScore W2055433725C154317977 @default.
- W2055433725 hasConceptScore W2055433725C159047783 @default.
- W2055433725 hasConceptScore W2055433725C202751555 @default.
- W2055433725 hasConceptScore W2055433725C207001950 @default.
- W2055433725 hasConceptScore W2055433725C2776178377 @default.
- W2055433725 hasConceptScore W2055433725C2780381497 @default.
- W2055433725 hasConceptScore W2055433725C2780625556 @default.
- W2055433725 hasConceptScore W2055433725C501734568 @default.
- W2055433725 hasConceptScore W2055433725C54355233 @default.
- W2055433725 hasConceptScore W2055433725C552990157 @default.
- W2055433725 hasConceptScore W2055433725C55493867 @default.
- W2055433725 hasConceptScore W2055433725C81885089 @default.
- W2055433725 hasConceptScore W2055433725C86803240 @default.
- W2055433725 hasLocation W20554337251 @default.
- W2055433725 hasLocation W20554337252 @default.
- W2055433725 hasOpenAccess W2055433725 @default.
- W2055433725 hasPrimaryLocation W20554337251 @default.
- W2055433725 hasRelatedWork W1522819024 @default.
- W2055433725 hasRelatedWork W1610246587 @default.
- W2055433725 hasRelatedWork W2005947640 @default.
- W2055433725 hasRelatedWork W2036888476 @default.
- W2055433725 hasRelatedWork W2046106364 @default.
- W2055433725 hasRelatedWork W2049529530 @default.
- W2055433725 hasRelatedWork W2086560865 @default.
- W2055433725 hasRelatedWork W2172117667 @default.
- W2055433725 hasRelatedWork W2417498263 @default.
- W2055433725 hasRelatedWork W2464301138 @default.
- W2055433725 isParatext "false" @default.
- W2055433725 isRetracted "false" @default.
- W2055433725 magId "2055433725" @default.
- W2055433725 workType "article" @default.