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• W2055436939 abstract "Multistate genetic switches play a crucial role during embryonic development and tumorigenesis. An archetypical example is the three-way switch regulating epithelial-hybrid-mesenchymal transitions. We devise a special WKB-based approach to investigate white Gaussian and shot noise effects on three-way switches, and construct an effective landscape in good quantitative agreement with stochastic simulations. This approach allows efficient analytical or numerical calculation of the landscape contours, the optimal path, and the state relative stability for general multicomponent multistate switches." @default.
• W2055436939 created "2016-06-24" @default.
• W2055436939 creator A5015852015 @default.
• W2055436939 creator A5030987631 @default.
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• W2055436939 date "2014-08-13" @default.
• W2055436939 modified "2023-09-26" @default.
• W2055436939 title "Construction of an Effective Landscape for Multistate Genetic Switches" @default.
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• W2055436939 doi "https://doi.org/10.1103/physrevlett.113.078102" @default.
• W2055436939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25170733" @default.
• W2055436939 hasPublicationYear "2014" @default.
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