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• W2055438067 abstract "The immunopathogenic mechanisms in three men with rapidly progressive glomerulonephritis and hemorrhagic pneumonitis were studied. Nephritis and fatal pulmonary hemorrhage occurred simultaneously in two patients. Typical Goodpasture's syndrome was defined in one by the presence of noncomplement-fixing IgG antiglomerular basement membrane (GBM) antibodies in his circulation, kidney, and lung. Immunofluorescent studies were negative in the second patient, although an immune complex pathogenesis was suggested by the presence of mixed cryoglobulinemia, decreased serum complement, and arteritis. The third patient also had anti-GBM-mediated nephritis, but his ultimately fatal pulmonary disease did not develop until after nephrectomy. Recurrence of the same anti-GBM nephritis was documented in his renal transplant at necropsy. It is suggested that Goodpasture's syndrome be restricted to patients with anti-GBM antibody-mediated nephritis and concomitant hemorrhagic pneumonitis." @default.
• W2055438067 created "2016-06-24" @default.
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• W2055438067 date "1971-07-01" @default.
• W2055438067 modified "2023-09-26" @default.
• W2055438067 title "Variant Goodpasture's Syndrome?" @default.
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• W2055438067 doi "https://doi.org/10.7326/0003-4819-75-1-67" @default.
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