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- W2055441029 abstract "A series of 328 patients with advanced cancers of the stomach, pancreas, liver, and biliary tract were treated with intensive fluoropyrimidine therapy, including 5-FU, 5-FUDR, intra-arterial infusions of 5-FU, and 5-FU plus radiotherapy. Survival patterns were analyzed with particular emphasis on survival over 1 year after treatment was begun. Patients with stomach cancer had median survivals of 5–7 1/2 months; over-all survival of more than a year was seen in 22%. Radiation therapy plus 5-FU was associated with slightly longer survival, as was prior resection of the primary tumor. Patients with pancreatic cancer survived four months median, with 12.5% surviving longer than 1 year. Survial was most dependent on extent of disease at the onset of therapy. Hepatobiliary cancer continued to present a very bleak prognosis. However, excellent responses occurred in 3/31 patients with liver cell or bile duct carcinoma. Intra-arterial infusions for liver involvement in these patients appeared to contribute little benefit to over-all survival, although dramatic responses were observed in two patients with primary liver tumors. It would appear that fluoropyrimidine therapy may modestly increase over-all survival in advanced stomach cancer. Survival in pancreatic cancer does not seem to be favorably influenced by this therapy." @default.
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- W2055441029 date "1974-01-01" @default.
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- W2055441029 title "Adenocarcinomas of stomach, pancreas, liver, and biliary tracts.Survival of 328 patients treated with fluoropyrimidine therapy" @default.
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- W2055441029 doi "https://doi.org/10.1002/1097-0142(197401)33:1<193::aid-cncr2820330128>3.0.co;2-s" @default.
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