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- W2055444005 abstract "Protein tyrosine kinases (PTKs) play an integral role in T cell activation and differentiation. Defects in the Src-family PTKs in mice and in T cell lines have resulted in variable defects in thymic development and in T cell antigen receptor (TCR) signal transduction. Here, three siblings are described with an autosomal recessive form of severe combined immunodeficiency disease (SCID) in which ZAP-70, a non-Src PTK, is absent as a result of mutations in the ZAP-70 gene. This absence is associated with defects in TCR signal transduction, suggesting an important functional role for ZAP-70." @default.
- W2055444005 created "2016-06-24" @default.
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- W2055444005 date "1994-06-10" @default.
- W2055444005 modified "2023-10-11" @default.
- W2055444005 title "ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency" @default.
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- W2055444005 doi "https://doi.org/10.1126/science.8202713" @default.
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