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- W2055446110 abstract "Mice deficient for the pre-TCRα (pTα) chain cannot form a pre-T cell receptor (TCR) and exhibit a severe defect in early T cell development, characterized by lack of “β selection” and impaired generation of double-positive (DP) thymocytes. Here, we demonstrate that intraperitoneal injection of CD3ε-specific antibodies into pTα−/− × RAG−/− mice or introduction of an activated p56 lck transgene in pTα−/− mice fully restores the number of DP thymocytes, and that expression of a transgenic pTα chain lacking its cytoplasmic portion can overcome all developmental defects associated with pTα deficiency. These results allow a better definition of the role of pTα in pre-TCR signal transduction and provide conclusive evidence that the cytoplasmic tail of pTα is not essential for pre-TCR signaling." @default.
- W2055446110 created "2016-06-24" @default.
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- W2055446110 date "1997-06-01" @default.
- W2055446110 modified "2023-10-15" @default.
- W2055446110 title "Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα" @default.
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- W2055446110 doi "https://doi.org/10.1016/s1074-7613(00)80446-x" @default.
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