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• W2055456476 endingPage "6389" @default.
• W2055456476 startingPage "6377" @default.
• W2055456476 abstract "Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral responses. This work provides an up-to-date overview of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer." @default.
• W2055456476 created "2016-06-24" @default.
• W2055456476 creator A5043470455 @default.
• W2055456476 creator A5067443169 @default.
• W2055456476 date "2014-11-01" @default.
• W2055456476 modified "2023-10-13" @default.
• W2055456476 title "Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer" @default.
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