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- W2055462416 abstract "From the first noninvasive visualization of the brains of patients with multiple sclerosis (MS) using MRI over 3 decades ago,1 most clinicians and investigators in the field assumed that this remarkable portal to the pathology of MS would provide a powerful tool for the analysis of subclinical disease activity and its importance in determining temporally associated clinical events and subsequent effects of this subclinical activity on the highly variable long-term clinical outcome of the disease. In many ways these expectations have been realized; MRI has become a cornerstone of modern diagnostic algorithms2 and is a powerful predictor of near and long-term outcome, at least when used early in the disease course.3 Similarly, clinical trialists recognized early on the face validity of this biomarker of subclinical activity, and anticipated that one or more MRI measures might prove to be a reliable surrogate marker for subsequent clinical outcomes that could facilitate drug discovery in MS. Realizing the latter expectation has proven much more elusive.Maria Pia Sormani and colleagues4 have been aggressively pursuing the validation of the short-term endpoints of relapsing-remitting MS therapeutic trials of clinically confirmed relapses and subclinical activity events on MRI as potential surrogates of accumulating clinical disability as measured by the Expanded Disability Status Scale …" @default.
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- W2055462416 date "2011-10-05" @default.
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- W2055462416 title "The long march to surrogates of meaningful clinical outcomes in MS trials: Are we there yet?" @default.
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- W2055462416 doi "https://doi.org/10.1212/wnl.0b013e3182364a63" @default.
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