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- W2055473332 endingPage "689" @default.
- W2055473332 startingPage "681" @default.
- W2055473332 abstract "In the intracellular redox state (GSH/GSSG) the cell plays a key role in the regulation and potentiation of the inflammatory response in lung cells. Glutathione and thioredoxin are the important protective antioxidants in the lungs. Regulation of intracellular redox glutathione and thioredoxin levels in response to reactive oxygen/nitrogen species and in inflammation should have critical effects on different lung cells on the activation of redox sensor/signal transduction pathways and various transcription factors. Possibly via the modification of cysteine residues, oxidative stress activates multiple stress kinase pathways and transcription factors nuclear factor-κB and activator protein-1, which differentially regulate the genes for proinflammatory cytokines as well as the protective antioxidant genes. Emerging data suggest that protein-S-thiolation, protein-S-nitrosation, and oxidation of protein-SH (formation of sulfenic, sulfinic, and sulfonic acids) are critical in redox signaling during normal physiology and under oxidative stress in controlling the cellular processes. In this review, we discuss the recent findings in the context of redox signaling during inflammation, pathology, and the role of redox modulating agents/dietary interventions either to inhibit abnormal signaling or induce/boost the endogenous antioxidant systems. Furthermore, this also provides information as to how antioxidants are involved in redox signaling to control inflammatory and oxidative stress in the lung." @default.
- W2055473332 created "2016-06-24" @default.
- W2055473332 creator A5042277388 @default.
- W2055473332 creator A5058348723 @default.
- W2055473332 creator A5064739348 @default.
- W2055473332 date "2006-03-01" @default.
- W2055473332 modified "2023-10-17" @default.
- W2055473332 title "Current Concepts of Redox Signaling in the Lungs" @default.
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- W2055473332 doi "https://doi.org/10.1089/ars.2006.8.681" @default.
- W2055473332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16677111" @default.
- W2055473332 hasPublicationYear "2006" @default.
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