FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055473792> ?p ?o ?g. }

• W2055473792 endingPage "85" @default.
• W2055473792 startingPage "79" @default.
• W2055473792 abstract "Polyphosphate is involved in resistance to stress in a number of bacterial species; however, its role in the virulence of Salmonella enterica serovars which differ in their host range has not been described. We examined the role of polyphosphate kinase in infection, growth and survival of S. Typhimurium (broad-host range) and S. Gallinarum (avian-adapted). We also used ppk mutants to assess the downstream effects on intracellular ATP levels. ppk mutants had significantly (P < 0.05) elevated ATP in stationary phase compared to the wild-type and, depending on the serovar, were defective in growth, survival and virulence. The virulence of S. Typhimurium ppk::SpcStr was significantly (P < 0.05) attenuated following oral infection of both Rhode Island Red chickens and BALB/c mice. In contrast, inactivation of the ppk gene of S. Gallinarum did not affect growth or virulence. The differential contribution of polyphosphate to the virulence of S. Typhimurium and S. Gallinarum may reflect aspects of the pathogenesis and host range of these serovars. The ppk mutant of both serovars survived significantly less well (P < 0.05) in a saline starvation-survival model, relative to the respective parent. The effect of ppk mutation on survival was formally described by fitting the data to the Weibull model and by estimation of kmax. Measurement of rpoS promoter activity using a lacZ transcriptional fusion demonstrated repression of rpoS in a ppk background, confirming a role for polyphosphate in RpoS induction. Together the data indicate the crucial importance of maintaining stable intracellular ATP during infection and nutritional stress. We suggest that polyphosphate plays a central role in homeostasis during growth and stress." @default.
• W2055473792 created "2016-06-24" @default.
• W2055473792 creator A5035906684 @default.
• W2055473792 creator A5036460937 @default.
• W2055473792 creator A5063613663 @default.
• W2055473792 creator A5068369120 @default.
• W2055473792 creator A5071214313 @default.
• W2055473792 creator A5073418297 @default.
• W2055473792 date "2007-01-01" @default.
• W2055473792 modified "2023-10-16" @default.
• W2055473792 title "Inactivation of ppk differentially affects virulence and disrupts ATP homeostasis in Salmonella enterica serovars Typhimurium and Gallinarum" @default.
• W2055473792 cites W1508139133 @default.
• W2055473792 cites W1514986543 @default.
• W2055473792 cites W1639192928 @default.
• W2055473792 cites W1813923248 @default.
• W2055473792 cites W1912410317 @default.
• W2055473792 cites W1966175891 @default.
• W2055473792 cites W1974315733 @default.
• W2055473792 cites W1983102189 @default.
• W2055473792 cites W1984141548 @default.
• W2055473792 cites W1995962422 @default.
• W2055473792 cites W2005978096 @default.
• W2055473792 cites W2006759559 @default.
• W2055473792 cites W2013295580 @default.
• W2055473792 cites W2025842817 @default.
• W2055473792 cites W2044218755 @default.
• W2055473792 cites W2088607504 @default.
• W2055473792 cites W2099399224 @default.
• W2055473792 cites W2116511990 @default.
• W2055473792 cites W2117805957 @default.
• W2055473792 cites W2120230644 @default.
• W2055473792 cites W2126732425 @default.
• W2055473792 cites W2127131582 @default.
• W2055473792 cites W2130046517 @default.
• W2055473792 cites W2133508938 @default.
• W2055473792 cites W2139885113 @default.
• W2055473792 cites W2148358470 @default.
• W2055473792 cites W2153130586 @default.
• W2055473792 cites W2156960269 @default.
• W2055473792 cites W2157800733 @default.
• W2055473792 cites W2161220379 @default.
• W2055473792 cites W3129911986 @default.
• W2055473792 cites W4298176137 @default.
• W2055473792 doi "https://doi.org/10.1016/j.resmic.2006.10.008" @default.
• W2055473792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17227702" @default.
• W2055473792 hasPublicationYear "2007" @default.
• W2055473792 type Work @default.
• W2055473792 sameAs 2055473792 @default.
• W2055473792 citedByCount "18" @default.
• W2055473792 countsByYear W20554737922013 @default.
• W2055473792 countsByYear W20554737922014 @default.
• W2055473792 countsByYear W20554737922015 @default.
• W2055473792 countsByYear W20554737922016 @default.
• W2055473792 countsByYear W20554737922018 @default.
• W2055473792 countsByYear W20554737922021 @default.
• W2055473792 crossrefType "journal-article" @default.
• W2055473792 hasAuthorship W2055473792A5035906684 @default.
• W2055473792 hasAuthorship W2055473792A5036460937 @default.
• W2055473792 hasAuthorship W2055473792A5063613663 @default.
• W2055473792 hasAuthorship W2055473792A5068369120 @default.
• W2055473792 hasAuthorship W2055473792A5071214313 @default.
• W2055473792 hasAuthorship W2055473792A5073418297 @default.
• W2055473792 hasConcept C101762097 @default.
• W2055473792 hasConcept C10389963 @default.
• W2055473792 hasConcept C104317684 @default.
• W2055473792 hasConcept C143065580 @default.
• W2055473792 hasConcept C150194340 @default.
• W2055473792 hasConcept C159047783 @default.
• W2055473792 hasConcept C2777712861 @default.
• W2055473792 hasConcept C2779607309 @default.
• W2055473792 hasConcept C2781065037 @default.
• W2055473792 hasConcept C523546767 @default.
• W2055473792 hasConcept C54355233 @default.
• W2055473792 hasConcept C60987743 @default.
• W2055473792 hasConcept C86803240 @default.
• W2055473792 hasConcept C89423630 @default.
• W2055473792 hasConceptScore W2055473792C101762097 @default.
• W2055473792 hasConceptScore W2055473792C10389963 @default.
• W2055473792 hasConceptScore W2055473792C104317684 @default.
• W2055473792 hasConceptScore W2055473792C143065580 @default.
• W2055473792 hasConceptScore W2055473792C150194340 @default.
• W2055473792 hasConceptScore W2055473792C159047783 @default.
• W2055473792 hasConceptScore W2055473792C2777712861 @default.
• W2055473792 hasConceptScore W2055473792C2779607309 @default.
• W2055473792 hasConceptScore W2055473792C2781065037 @default.
• W2055473792 hasConceptScore W2055473792C523546767 @default.
• W2055473792 hasConceptScore W2055473792C54355233 @default.
• W2055473792 hasConceptScore W2055473792C60987743 @default.
• W2055473792 hasConceptScore W2055473792C86803240 @default.
• W2055473792 hasConceptScore W2055473792C89423630 @default.
• W2055473792 hasIssue "1" @default.
• W2055473792 hasLocation W20554737921 @default.
• W2055473792 hasLocation W20554737922 @default.
• W2055473792 hasOpenAccess W2055473792 @default.
• W2055473792 hasPrimaryLocation W20554737921 @default.
• W2055473792 hasRelatedWork W1799115436 @default.
• W2055473792 hasRelatedWork W2102543151 @default.
• W2055473792 hasRelatedWork W2155281470 @default.

• next