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• W2055485330 abstract "Two surgical techniques are commonly used for small intestinal transplantation: heterotopic (accessory) intestinal grafting (HIT), where the small bowel is initially defunctioned with restoration of intestinal continuity at a later date, and orthotopic (in continuity) intestinal grafting (OIT), where the small bowel is immediately anastomosed to the native intestine. The present experiments were undertaken to compare the advantages and disadvantages of these two surgical models. Graft barrier function (intestinal permeability), intestinal histology, and graft survival were evaluated after heterotopic and orthotopic intestinal transplantation in the following groups of rats: group 1: isografts, group 2: untreated allografts, group 3: low-dose cyclosporine—treated allografts (subcutaneous CsA 2 mg/kg/day), and group 4: high-dose CsA-treated allografts (subcutaneous CsA 4 mg/kg/day). Intestinal permeability was consistently higher after HIT than OIT in all of the groups (ANOVA; P<0.01). Histological evidence of rejection appeared earlier after HIT than OIT (HIT 5th postoperative day (POD); OIT 7th POD; P<0.05). The mean survival of untreated allografts was longer after HIT than OIT (HIT 15.7±6 days, OIT 9.2±1 days, P<0.05). The rats treated with low-dose CsA after OIT lost weight and died of rejection after a mean survival time of 17.7±2 days, while the rats treated with low-dose CsA after HIT remained well until sacrifice on POD 28 (P<0.01). The rats with isografts and rats with allografts treated with high-dose CsA remained well after HIT and OIT until sacrifice on the 28th POD. These data suggest that nutrients and other factors in the succus entericus may improve gut barrier function and delay the onset of rejection after OIT. However, rejection of the orthotopic intestinal graft is usually fatal, while rejection of the heterotopic graft is often surprisingly well tolerated. These factors must be taken" @default.
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• W2055485330 date "1991-05-01" @default.
• W2055485330 modified "2023-10-02" @default.
• W2055485330 title "A COMPARISON OF HETEROTOPIC AND ORTHOTOPIC INTESTINAL TRANSPLANTATION IN RATS" @default.
• W2055485330 doi "https://doi.org/10.1097/00007890-199105000-00003" @default.
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