Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055486537> ?p ?o ?g. }
- W2055486537 endingPage "61" @default.
- W2055486537 startingPage "55" @default.
- W2055486537 abstract "The tonic activation of extrasynaptic GABAA receptors by extracellular GABA provides a powerful means of regulating neuronal excitability. A consistent finding from studies that have used various models of temporal lobe epilepsy is that tonic GABAA receptor-mediated conductances are largely preserved in epileptic brain (in contrast to synaptic inhibition which is often reduced). Tonic inhibition is therefore an attractive target for antiepileptic drugs. However, the network consequences of a commonly used approach to augment tonic GABAA receptor-mediated conductances by global manipulation of extracellular GABA are difficult to predict without understanding how epileptogenesis alters the pharmacology and GABA sensitivity of tonic inhibition, and how manipulation of tonic conductances modulates the output of individual neurons. Here we review the current literature on epilepsy-associated changes in tonic GABAA receptor-mediated signalling, and speculate about possible effects they have at the network level. This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'." @default.
- W2055486537 created "2016-06-24" @default.
- W2055486537 creator A5075289165 @default.
- W2055486537 creator A5081465083 @default.
- W2055486537 date "2013-06-01" @default.
- W2055486537 modified "2023-09-26" @default.
- W2055486537 title "Tonic GABAA receptor-mediated signalling in temporal lobe epilepsy" @default.
- W2055486537 cites W1494945459 @default.
- W2055486537 cites W1503335897 @default.
- W2055486537 cites W1505903665 @default.
- W2055486537 cites W1520068218 @default.
- W2055486537 cites W1550227666 @default.
- W2055486537 cites W1603732963 @default.
- W2055486537 cites W1633786496 @default.
- W2055486537 cites W1758735213 @default.
- W2055486537 cites W1906116459 @default.
- W2055486537 cites W1926479678 @default.
- W2055486537 cites W1947066063 @default.
- W2055486537 cites W1965865340 @default.
- W2055486537 cites W1966927767 @default.
- W2055486537 cites W1973115552 @default.
- W2055486537 cites W1973787480 @default.
- W2055486537 cites W1974016987 @default.
- W2055486537 cites W1982890379 @default.
- W2055486537 cites W1983635597 @default.
- W2055486537 cites W1985667126 @default.
- W2055486537 cites W1987520241 @default.
- W2055486537 cites W1987868569 @default.
- W2055486537 cites W1990429945 @default.
- W2055486537 cites W1992147695 @default.
- W2055486537 cites W1996957734 @default.
- W2055486537 cites W1997185390 @default.
- W2055486537 cites W1997964026 @default.
- W2055486537 cites W2001479737 @default.
- W2055486537 cites W2005475009 @default.
- W2055486537 cites W2007778040 @default.
- W2055486537 cites W2007830270 @default.
- W2055486537 cites W2011469680 @default.
- W2055486537 cites W2011747330 @default.
- W2055486537 cites W2012662249 @default.
- W2055486537 cites W2012898751 @default.
- W2055486537 cites W2013491471 @default.
- W2055486537 cites W2015236906 @default.
- W2055486537 cites W2016321438 @default.
- W2055486537 cites W2017160535 @default.
- W2055486537 cites W2019043248 @default.
- W2055486537 cites W2020420256 @default.
- W2055486537 cites W2022726353 @default.
- W2055486537 cites W2023871512 @default.
- W2055486537 cites W2024561575 @default.
- W2055486537 cites W2028756092 @default.
- W2055486537 cites W2029038733 @default.
- W2055486537 cites W2030857678 @default.
- W2055486537 cites W2031849673 @default.
- W2055486537 cites W2031872972 @default.
- W2055486537 cites W2031887755 @default.
- W2055486537 cites W2046426488 @default.
- W2055486537 cites W2046598509 @default.
- W2055486537 cites W2047361402 @default.
- W2055486537 cites W2048089421 @default.
- W2055486537 cites W2050343921 @default.
- W2055486537 cites W2056571308 @default.
- W2055486537 cites W2057724638 @default.
- W2055486537 cites W2061947653 @default.
- W2055486537 cites W2062954928 @default.
- W2055486537 cites W2065031748 @default.
- W2055486537 cites W2065650455 @default.
- W2055486537 cites W2067446126 @default.
- W2055486537 cites W2068805802 @default.
- W2055486537 cites W2069079367 @default.
- W2055486537 cites W2069586118 @default.
- W2055486537 cites W2069650489 @default.
- W2055486537 cites W2070510853 @default.
- W2055486537 cites W2072472879 @default.
- W2055486537 cites W2072702213 @default.
- W2055486537 cites W2072962057 @default.
- W2055486537 cites W2073007413 @default.
- W2055486537 cites W2080218996 @default.
- W2055486537 cites W2085556169 @default.
- W2055486537 cites W2086267716 @default.
- W2055486537 cites W2087291581 @default.
- W2055486537 cites W2087356150 @default.
- W2055486537 cites W2088143216 @default.
- W2055486537 cites W2088296164 @default.
- W2055486537 cites W2093301371 @default.
- W2055486537 cites W2098864351 @default.
- W2055486537 cites W2099631417 @default.
- W2055486537 cites W2101268699 @default.
- W2055486537 cites W2109251081 @default.
- W2055486537 cites W2109271430 @default.
- W2055486537 cites W2109792092 @default.
- W2055486537 cites W2112075758 @default.
- W2055486537 cites W2116883357 @default.
- W2055486537 cites W2118915904 @default.
- W2055486537 cites W2124909604 @default.
- W2055486537 cites W2129455633 @default.
- W2055486537 cites W2131046634 @default.
- W2055486537 cites W2131300789 @default.