FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055492208> ?p ?o ?g. }

• W2055492208 endingPage "62" @default.
• W2055492208 startingPage "49" @default.
• W2055492208 abstract "In Chinese hamster ovary (CHO) cells expressing the cloned guinea-pig Y1 receptor, the saturable, receptor-linked internalization of NPY (NPY)-related peptides showed the rank order of human/rat neuropeptide Y (hNPY)>pig/rat peptide YY (pPYY)>=(Pro(34))human PYY>(Leu(31),Pro(34))hNPY>(Leu(31),Pro(34))hPYY>>BVD-11 (a selective Y1 antagonist). All agonists accessed similar numbers of Y1 sites in particulates from disrupted cells, with relatively small affinity variation. The rate of internalization could significantly depend on the overall interactivity of the agonist peptide (reflected in sensitivity to chaotropic agents, as well as in the level of non-saturable binding and internalization). Concentration-dependent inhibition of the agonist-driven CHO-Y1 internalization was found with filipin III (a cholesterol-complexing macrolide), and confirmed with inhibitors of clathrin lattice formation, phenylarsine oxide (PAO) and sucrose. In the concentration range affecting Y1 internalization, none of the above treatments or agents significantly alter agonist affinity for Y1 cell surface or particulate receptors. Largely similar responses to the above inhibitors were observed in CHO-Y1 cells for internalization of human transferrin. Internalization of CHO-Y1 receptor apparently is driven by NPY in strong preference to other naturally encountered agonists. At 37 degrees C, most of the internalized receptor is rapidly recycled through endosome-like membrane elements, detectable in Percoll gradients." @default.
• W2055492208 created "2016-06-24" @default.
• W2055492208 creator A5003519144 @default.
• W2055492208 creator A5007797524 @default.
• W2055492208 creator A5013846051 @default.
• W2055492208 creator A5051885955 @default.
• W2055492208 creator A5053874640 @default.
• W2055492208 creator A5059198766 @default.
• W2055492208 creator A5063731029 @default.
• W2055492208 creator A5088664449 @default.
• W2055492208 date "2002-07-01" @default.
• W2055492208 modified "2023-09-27" @default.
• W2055492208 title "Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling" @default.
• W2055492208 cites W1495317745 @default.
• W2055492208 cites W1519659681 @default.
• W2055492208 cites W1553513611 @default.
• W2055492208 cites W1582157044 @default.
• W2055492208 cites W1603151752 @default.
• W2055492208 cites W1606297570 @default.
• W2055492208 cites W189543407 @default.
• W2055492208 cites W1965530119 @default.
• W2055492208 cites W1972292461 @default.
• W2055492208 cites W1977296630 @default.
• W2055492208 cites W1978378468 @default.
• W2055492208 cites W1979300325 @default.
• W2055492208 cites W1986151431 @default.
• W2055492208 cites W1996991086 @default.
• W2055492208 cites W1999698134 @default.
• W2055492208 cites W2000959507 @default.
• W2055492208 cites W2002017388 @default.
• W2055492208 cites W2002023798 @default.
• W2055492208 cites W2003334958 @default.
• W2055492208 cites W2004849216 @default.
• W2055492208 cites W2013184139 @default.
• W2055492208 cites W2017201573 @default.
• W2055492208 cites W2020733551 @default.
• W2055492208 cites W2023299948 @default.
• W2055492208 cites W2023788551 @default.
• W2055492208 cites W2025502308 @default.
• W2055492208 cites W2028645725 @default.
• W2055492208 cites W2036329205 @default.
• W2055492208 cites W2036968856 @default.
• W2055492208 cites W2041933313 @default.
• W2055492208 cites W2043813981 @default.
• W2055492208 cites W2043914892 @default.
• W2055492208 cites W2052714408 @default.
• W2055492208 cites W2057306553 @default.
• W2055492208 cites W2060759854 @default.
• W2055492208 cites W2061716134 @default.
• W2055492208 cites W2064110992 @default.
• W2055492208 cites W2065943239 @default.
• W2055492208 cites W2072454705 @default.
• W2055492208 cites W2079679063 @default.
• W2055492208 cites W2079681415 @default.
• W2055492208 cites W2087665741 @default.
• W2055492208 cites W2088013881 @default.
• W2055492208 cites W2092245967 @default.
• W2055492208 cites W2124442196 @default.
• W2055492208 cites W2125233904 @default.
• W2055492208 cites W2128963767 @default.
• W2055492208 cites W2135005617 @default.
• W2055492208 cites W2144692292 @default.
• W2055492208 cites W2164945120 @default.
• W2055492208 cites W281407840 @default.
• W2055492208 cites W4231136244 @default.
• W2055492208 cites W4242772725 @default.
• W2055492208 cites W4253293906 @default.
• W2055492208 doi "https://doi.org/10.1016/s0167-0115(02)00094-0" @default.
• W2055492208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12137966" @default.
• W2055492208 hasPublicationYear "2002" @default.
• W2055492208 type Work @default.
• W2055492208 sameAs 2055492208 @default.
• W2055492208 citedByCount "28" @default.
• W2055492208 countsByYear W20554922082015 @default.
• W2055492208 crossrefType "journal-article" @default.
• W2055492208 hasAuthorship W2055492208A5003519144 @default.
• W2055492208 hasAuthorship W2055492208A5007797524 @default.
• W2055492208 hasAuthorship W2055492208A5013846051 @default.
• W2055492208 hasAuthorship W2055492208A5051885955 @default.
• W2055492208 hasAuthorship W2055492208A5053874640 @default.
• W2055492208 hasAuthorship W2055492208A5059198766 @default.
• W2055492208 hasAuthorship W2055492208A5063731029 @default.
• W2055492208 hasAuthorship W2055492208A5088664449 @default.
• W2055492208 hasConcept C102747710 @default.
• W2055492208 hasConcept C118303440 @default.
• W2055492208 hasConcept C126322002 @default.
• W2055492208 hasConcept C134018914 @default.
• W2055492208 hasConcept C139770010 @default.
• W2055492208 hasConcept C170493617 @default.
• W2055492208 hasConcept C175656101 @default.
• W2055492208 hasConcept C185592680 @default.
• W2055492208 hasConcept C2778575167 @default.
• W2055492208 hasConcept C2778938600 @default.
• W2055492208 hasConcept C2780796126 @default.
• W2055492208 hasConcept C2781161309 @default.
• W2055492208 hasConcept C28005876 @default.
• W2055492208 hasConcept C55493867 @default.
• W2055492208 hasConcept C71924100 @default.

• next