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- W2055503205 abstract "Semantic dementia (SD) is a unique syndrome in the frontotemporal lobar degeneration spectrum. Typically presenting as a progressive, fluent anomic aphasia, SD is the paradigmatic disorder of semantic memory with a characteristic anatomical profile of asymmetric, selective antero-inferior temporal lobe atrophy. Histopathologically, most cases show a specific pattern of abnormal deposition of protein TDP-43. This relatively close clinical, anatomical and pathological correspondence suggests SD as a promising target for future therapeutic trials. Here, we discuss outstanding nosological and neurobiological challenges posed by the syndrome and propose a pathophysiological model of SD based on sequential, regionally determined disintegration of a vulnerable neural network." @default.
- W2055503205 created "2016-06-24" @default.
- W2055503205 creator A5004703049 @default.
- W2055503205 creator A5068675261 @default.
- W2055503205 date "2011-06-29" @default.
- W2055503205 modified "2023-09-26" @default.
- W2055503205 title "Semantic Dementia: a specific network-opathy" @default.
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- W2055503205 doi "https://doi.org/10.1007/s12031-011-9586-3" @default.
- W2055503205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3207124" @default.
- W2055503205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21710360" @default.
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